Herr Brian D, Marzo Sam J
Department of Otolaryngology--Head and Neck Surgery, Loyola University Medical Center, IL 60153, USA.
Otolaryngol Head Neck Surg. 2005 Apr;132(4):527-31. doi: 10.1016/j.otohns.2004.09.138.
Patients with sudden sensorineural hearing loss (SSHL) can benefit from systemic steroid therapy. Unfortunately, some patients are not candidates for steroid therapy due to concern over possible complications. Furthermore, not all patients will benefit from steroid administration. This study evaluates the potential benefits and safety of treating patients with SSHL refractory to oral steroids with intratympanic steroid therapy.
A retrospective case review was performed on all patients who presented with sudden sensorineural hearing loss refractory to oral steroid therapy during the past year. Seventeen patients were identified. All patients underwent intratympanic steroid administration, via MicroWick placement and/or round window catheter placement.
Nine patients with sudden sensorineural hearing loss showed an improvement with intratympanic steroid therapy, consisting of MicroWick placement with dexamethasone drop (Decadron) administration for 1-2 weeks and/or round window catheter placement with steroid perfusion. Only one of the patients presenting with hearing loss present for greater than 8 weeks benefited from intratympanic therapy. Complications were few and included tympanic membrane perforation, chronic otitis media, dysequilibrium, and dysguesia.
Intratympanic steroid therapy can be beneficial in treating patients with sudden sensorineural hearing loss refractory to oral steroid use.
C.
突发性感音神经性听力损失(SSHL)患者可从全身类固醇治疗中获益。遗憾的是,由于担心可能出现的并发症,一些患者不适合接受类固醇治疗。此外,并非所有患者都会从类固醇给药中受益。本研究评估了鼓室内类固醇治疗对口服类固醇难治性SSHL患者的潜在益处和安全性。
对过去一年中出现口服类固醇治疗难治性突发性感音神经性听力损失的所有患者进行回顾性病例分析。共确定了17例患者。所有患者均通过微芯放置和/或圆窗导管放置进行鼓室内类固醇给药。
9例突发性感音神经性听力损失患者经鼓室内类固醇治疗后听力有所改善,治疗方法包括放置微芯并滴注地塞米松(德沙美松)1 - 2周和/或通过圆窗导管灌注类固醇。在听力损失超过8周的患者中,只有1例从鼓室内治疗中获益。并发症较少,包括鼓膜穿孔、慢性中耳炎、失衡和味觉障碍。
鼓室内类固醇治疗对口服类固醇难治性突发性感音神经性听力损失患者可能有益。
C级