Farhadi Mohammad, Noorbakhsh Samileh, Tabatabaei Azardokht, Daneshi Ahamad, Darestani Sahar Ghavidel, Jomeh Emam
ENT, Head & Neck Surgery Research Center, Rasoul Akram Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Research Center of Pediatric Infectious Diseases, Hazrat Rasul Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Basic Clin Neurosci. 2013 Summer;4(3):244-9.
Serum Anti endothelial Cell Antibodies (AECAs) play a prominent role in idiopathic Sensorineural Hearing Loss (SNHL) in that they induce vascular damage (immune mediated). The of the current study is To compare AECAs in serum and perilymphatic fluid of idiopathic SNHL children (<15y) undergoing cochlear implant surgery.
This was a cross sectional study performed in the cochlear implant ward in Rasoul Akram hospital, Tehran, Iran (2008 -2010) on 99 SNHL children undergoing cochlear implant surgery. The data collected from47 idiopathic and 52 non-idiopathic SNHL cases. AECAs were measured by indirect immuno fluorescence assay and compared in sera and perilymphatic fluids between the two groups. P-value < 0.05 was considered significant.
Idiopathic SNHL was diagnosed in 47.5% of cases. Positive AECA results in serum and perilymphatic fluid were 10% and 12%, respectively. Although AECA results in perilymphatic fluids were different between idiopathic and non-Idiopathic SNHL patients (PV < 0.05), AECAs in serum showed no significant difference between the two (PV = 0.1). No significant difference was detected between the mean age of idiopathic and non-idiopathic SNHL patients with positive AECAs in serum and perilymphatic fluids (PV = 0.2; PV = 0.2).
Idiopathic SNHL was diagnosed in 47.5% of studied cases. Idiopathic SNHL has a poor out come in children. In cases with idiopathic SNHL, finding AECAs in perilymphatic fluids are more valuable than in the serum. We suggest that serum and perilymphatic fluids testing for AECAs would be helpful in management of idiopathic SNHL cases. Specific immunosuppressive treatments for selected cases suffering from Idiopathic SNHL (only in those older than 5) might be successful in disease management. However, this theory should first be validated by randomized clinical trials.
血清抗内皮细胞抗体（AECAs）在特发性感音神经性听力损失（SNHL）中起着重要作用，因为它们会引发血管损伤（免疫介导）。本研究的目的是比较接受人工耳蜗植入手术的特发性SNHL儿童（<15岁）血清和外淋巴液中的AECAs。
这是一项横断面研究，于2008 - 2010年在伊朗德黑兰拉苏勒·阿克拉姆医院的人工耳蜗病房对99例接受人工耳蜗植入手术的SNHL儿童进行。收集了47例特发性和52例非特发性SNHL病例的数据。通过间接免疫荧光法检测AECAs，并比较两组血清和外淋巴液中的AECAs。P值<0.05被认为具有统计学意义。
47.5%的病例被诊断为特发性SNHL。血清和外淋巴液中AECA阳性结果分别为10%和12%。虽然特发性和非特发性SNHL患者外淋巴液中的AECA结果不同（PV < 0.05），但血清中的AECAs在两者之间无显著差异（PV = 0.1）。血清和外淋巴液中AECA阳性的特发性和非特发性SNHL患者的平均年龄之间未检测到显著差异（PV = 0.2；PV = 0.2）。
47.5%的研究病例被诊断为特发性SNHL。特发性SNHL在儿童中的预后较差。在特发性SNHL病例中，在外淋巴液中发现AECAs比在血清中更有价值。我们建议检测血清和外淋巴液中的AECAs有助于特发性SNHL病例的管理。针对选定的特发性SNHL病例（仅适用于5岁以上患者）进行特定的免疫抑制治疗可能会成功控制疾病。然而，这一理论首先应通过随机临床试验进行验证。
