繁育转基因啮齿动物：追踪与解决繁殖性能问题的小贴士

Breeding genetically modified rodents: tips for tracking and troubleshooting reproductive performance.

作者信息

Murray Kathleen A, Parker Nancy Jean

机构信息

Charles River Laboratories, Transgenic Services, Wilmington, MA 01887, USA.

出版信息

Lab Anim (NY). 2005 Apr;34(4):36-41. doi: 10.1038/laban0405-36.

DOI:10.1038/laban0405-36

PMID:15806089

Abstract

Infertility or reduced fertility in genetically modified mouse strains represents a serious bottleneck for planned research projects. The authors describe simple methods for troubleshooting poor reproductive performance in breeding colonies and introduce various means of assisted reproduction that might be used to 'rescue' infertile lines.

摘要

基因改造小鼠品系中的不育或生育力下降是计划中的研究项目的一个严重瓶颈。作者描述了排查繁殖群体中繁殖性能不佳问题的简单方法，并介绍了可用于“拯救”不育品系的各种辅助生殖手段。