转基因小鼠设施中意外结果的管理。
Management of unanticipated outcomes in transgenic mouse facilities.
作者信息
Pritt Stacy, Cozine Kerri, Warren Henry
机构信息
Covance Research Products, Inc., Denver, PA 17517, USA.
出版信息
Lab Anim (NY). 2006 Apr;35(4):27-30. doi: 10.1038/laban0406-27.
PMID:16582897
Abstract
Experimental manipulations of rodents may result in unexpected adverse phenotypes that present problems from both regulatory and animal care-veterinary perspectives. The authors discuss the implications of unanticipated outcomes and describe a cage card-based tracking system used at the Harvard Medical School for the early detection and handling of unanticipated phenotypes in genetically altered rodents.
摘要
对啮齿动物进行实验操作可能会导致意外的不良表型，这从监管和动物护理-兽医的角度来看都存在问题。作者讨论了意外结果的影响，并描述了哈佛医学院使用的一种基于笼卡的追踪系统，用于早期检测和处理基因改造啮齿动物中的意外表型。
相似文献
1
Management of unanticipated outcomes in transgenic mouse facilities.转基因小鼠设施中意外结果的管理。
Lab Anim (NY). 2006 Apr;35(4):27-30. doi: 10.1038/laban0406-27.
2
Comment on "Barrier facilities for transgenic rodents in academic centers--a two-edged sword".关于“学术中心转基因啮齿动物的屏障设施——一把双刃剑”的评论
Comp Med. 2003 Apr;53(2):116-8; author reply 118.
3
Behavioral phenotyping of rodents.啮齿动物的行为表型分析
Comp Med. 2003 Apr;53(2):140-6.
4
The role of the veterinary staff in mouse breeding colony management.兽医人员在小鼠繁殖种群管理中的作用。
Lab Anim (NY). 2005 Apr;34(4):45-9. doi: 10.1038/laban0405-45.
5
Should you count your mice before they're weaned?你应该在小鼠断奶前就数它们吗？
Lab Anim (NY). 2006 Jan;35(1):15. doi: 10.1038/laban0106-15a.
6
Barrier facilities for transgenic rodents in academic centers--a two-edged sword.学术中心转基因啮齿动物的屏障设施——一把双刃剑。
Comp Med. 2002 Oct;52(5):397-402.
7
Should you count your mice before they're weaned? Start counting.在小鼠断奶前就该开始计数吗？那就开始数吧。
Lab Anim (NY). 2006 Jan;35(1):17. doi: 10.1038/laban0106-17.
8
Should you count your mice before they're weaned? Pool the pups.在小鼠断奶前就计数合适吗？把幼崽集中起来。
Lab Anim (NY). 2006 Jan;35(1):15-6. doi: 10.1038/laban0106-15b.
9
Animal models of ischemic stroke: balancing experimental aims and animal care.缺血性中风的动物模型：平衡实验目的与动物护理
Comp Med. 2004 Oct;54(5):486-96.
10
The Study Support Associate: an alternative to the traditional animal care position.学习支持助理：传统动物护理岗位的替代选择。
Lab Anim (NY). 2006 Jan;35(1):34-8. doi: 10.1038/laban0106-34.
Zotero 插件