细胞色素P450 1B1（CYP1B1）、谷胱甘肽S-转移酶A1（GSTA1）、醌氧化还原酶1（NQO1）和N-乙酰基转移酶2（NAT2）的基因多态性与肺癌风险
Genetic polymorphisms in CYP1B1, GSTA1, NQO1 and NAT2 and the risk of lung cancer.
作者信息
Sørensen Mette, Autrup Herman, Tjønneland Anne, Overvad Kim, Raaschou-Nielsen Ole
机构信息
Institute of Cancer Epidemiology, The Danish Cancer Society, Strandboulevarden 49, DK-2100 Copenhagen O, Denmark.
出版信息
Cancer Lett. 2005 Apr 28;221(2):185-90. doi: 10.1016/j.canlet.2004.11.012.
In a population-based case-cohort study, we have investigated the occurrence of lung cancer in relation to polymorphisms in the phase I gene cytochrome P450 1B1 and in the phase II genes glutathione S-transferase A1, NAD(P)H quinone oxidoreductase and N-acetyltransferase 2 (NAT2). Among 54,220 cohort members, 265 lung cancer cases were identified and a sub-cohort comprising 272 individuals was used for comparison. No overall associations were found between the polymorphisms and risk of lung cancer. The NAT2 fast acetylator genotype seemed to be protective against lung cancer in light smokers (< or =20 cigarettes/day) and not among heavy smokers (>20 cigarettes/day).
在一项基于人群的病例队列研究中，我们调查了肺癌的发生与Ⅰ相基因细胞色素P450 1B1以及Ⅱ相基因谷胱甘肽S-转移酶A1、NAD(P)H醌氧化还原酶和N-乙酰转移酶2（NAT2）多态性之间的关系。在54220名队列成员中，确定了265例肺癌病例，并使用一个由272名个体组成的亚队列进行比较。未发现这些多态性与肺癌风险之间存在总体关联。NAT2快速乙酰化基因型似乎对轻度吸烟者（≤20支/天）有预防肺癌的作用，而在重度吸烟者（>20支/天）中则没有。
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