Lou Yuqing, Li Rong, Xiong Liwen, Gu Aiqin, Shi Chunlei, Chu Tianqing, Zhang Xueyan, Gu Ping, Zhong Hua, Wen Shaojun, Han Baohui
Department of Pulmonary, Shanghai Chest Hospital, Shanghai Jiaotong University, 241 West Huaihai Road, Shanghai, 200030, People's Republic of China.
Tumour Biol. 2013 Dec;34(6):3967-79. doi: 10.1007/s13277-013-0985-7. Epub 2013 Jul 14.
No clear consensus has been reached on the
NAD(P)H: quinone oxidoreductase 1 (NQO1) gene C609T polymorphism and lung cancer risk. We performed a meta-analysis to summarize the possible association. We conducted a computer retrieval of PubMed and Embase databases prior to May 2013. References of retrieved articles were also screened. The fixed-effects model and the random-effects model were applied for dichotomous outcomes to combine the results of the individual studies. According to the inclusion criteria, 25 articles (32 studies) were finally included. There was no statistical association between C609T polymorphism and lung cancer risk in overall, East Asians, African Americans, or Hispanics. In Caucasians, a significant association was found in allele comparison model (T vs. C) (P = 0.04, OR = 1.09, 95% CI 1.00-1.19, P(heterogeneity) = 0.24, fixed-effects model). In the subgroup of squamous cell carcinoma, a borderline significance could be found in the dominant genetic model (TT + CT vs. CC) (P = 0.05, OR = 1.20, 95% CI 1.00-1.43, P(heterogeneity) = 0.65, fixed-effects model). Significant association could also be found in allele comparison (T vs. C) (P = 0.03, OR = 1.21, 95% CI 1.01-1.44, P(heterogeneity) = 0.68, fixed-effects model). In the subgroup of small cell lung cancer risk, significant association were found in allele comparison (T vs. C) (P = 0.03, OR = 1.68, 95%CI 1.05-2.68, P(heterogeneity) = 0.10, random-effects model) and in the homozygote comparison (TT vs. CC) (P = 0.02, OR = 2.79, 95% CI 1.14-6.85, P heterogeneity = 0.72, fixed-effects model). No association was observed in adenocarcinoma subgroup. Our study suggested that NQO1 C609T polymorphism might associate with lung cancer risk in Caucasians. This polymorphism might also associate with squamous cell carcinoma and small cell lung cancer risk.
关于烟酰胺腺嘌呤二核苷酸磷酸（NAD(P)H）：醌氧化还原酶1（NQO1）基因C609T多态性与肺癌风险，尚未达成明确共识。我们进行了一项荟萃分析以总结可能的关联。在2013年5月之前，我们对PubMed和Embase数据库进行了计算机检索。还对检索到的文章的参考文献进行了筛选。对于二分结局，应用固定效应模型和随机效应模型来合并各个研究的结果。根据纳入标准，最终纳入了25篇文章（32项研究）。在总体、东亚人、非裔美国人或西班牙裔中，C609T多态性与肺癌风险之间无统计学关联。在白种人中，在等位基因比较模型（T与C）中发现显著关联（P = 0.04，OR = 1.09，95%CI 1.00 - 1.19，P(异质性)= 0.24，固定效应模型）。在鳞状细胞癌亚组中，在显性遗传模型（TT + CT与CC）中可发现临界显著性（P = 0.05，OR = 1.20，95%CI 1.00 - 1.43，P(异质性)= 0.65，固定效应模型）。在等位基因比较（T与C）中也可发现显著关联（P = 0.03，OR = 1.21，95%CI 1.01 - 1.44，P(异质性)= 0.68固定效应模型）。在小细胞肺癌风险亚组中，在等位基因比较（T与C）中发现显著关联（P = 0.03，OR = 1.68，95%CI 1.05 - 2.68，P(异质性)= 0.10，随机效应模型），在纯合子比较（TT与CC）中也发现显著关联（P = 0.02，OR = 2.79，95%CI 1.14 - 6.85，P异质性 = 0.72，固定效应模型）。在腺癌亚组中未观察到关联。我们的研究表明，NQO1 C609T多态性可能与白种人的肺癌风险相关。这种多态性也可能与鳞状细胞癌和小细胞肺癌风险相关。
