Liu Chang, Cui Wei, Cong Lin, Wang Li, Ruan Xinjian, Jia Jia, Liu Yanfang, Jia Xiaoyan, Zhang Xia
From the Department of Medical Oncology, The Military General Hospital of Beijing PLA, Beijing, China (CL, LW, XR, JJ, YL, XJ, XZ); Department of General Surgery, The Military General Hospital of Beijing PLA, Beijing, China (WC); and Department of Dermatology, The Military General Hospital of Beijing PLA, Beijing, China (LC).
Medicine (Baltimore). 2015 Dec;94(49):e1947. doi: 10.1097/MD.0000000000001947.
To further investigate the association between NAT2 polymorphisms and lung cancer susceptibility.In terms of phenotypes, we investigated the acetylator status of NAT2 polymorphisms associated with lung cancer risk. Additionally, in view of genotypes, we mainly analyzed 5 single nucleotide polymorphisms (SNPs) in NAT2 gene, namely C282T, A803G, C481T, G590A, and G857A. Twenty-six eligible studies were included in our meta-analysis by searching PubMed, Embase, and CNKI databases. We used odds ratios (ORs) with corresponding 95% confidence intervals (CIs) to evaluate the susceptibility to lung cancer associated with NAT2 polymorphisms.Overall, based on phenotypes, the pooled ORs showed no significant association between NAT2 polymorphisms and lung cancer susceptibility. In the subgroup analyses by ethnicity and source of control, there was still no significant association. In terms of genotypes, overall, no obvious relationship was observed between NAT2 polymorphisms and lung cancer risk. But increased risk of lung cancer was found in association with NAT2 C282T polymorphism (TT vs. CC + TC: OR = 1.58, 95% CI = 1.11-2.25).Our meta-analysis demonstrates that TT genotype in NAT2 C282T polymorphism may be a risk factor for lung cancer susceptibility. Additionally, the acetylator status of 5 SNPs in NAT2 gene may not be associated with lung cancer risk.
为进一步研究NAT2基因多态性与肺癌易感性之间的关联。在表型方面，我们研究了与肺癌风险相关的NAT2基因多态性的乙酰化状态。此外，从基因型角度，我们主要分析了NAT2基因中的5个单核苷酸多态性（SNP），即C282T、A803G、C481T、G590A和G857A。通过检索PubMed、Embase和CNKI数据库，我们的荟萃分析纳入了26项符合条件的研究。我们使用比值比（OR）及相应的95%置信区间（CI）来评估与NAT2基因多态性相关的肺癌易感性。总体而言，基于表型，汇总的OR显示NAT2基因多态性与肺癌易感性之间无显著关联。在按种族和对照来源进行的亚组分析中，仍无显著关联。在基因型方面，总体而言，未观察到NAT2基因多态性与肺癌风险之间存在明显关系。但发现NAT2基因C282T多态性与肺癌风险增加有关（TT与CC + TC相比：OR = 1.58，95% CI = 1.11 - 2.25）。我们的荟萃分析表明，NAT2基因C282T多态性中的TT基因型可能是肺癌易感性的一个危险因素。此外，NAT2基因中5个SNP的乙酰化状态可能与肺癌风险无关。
