奥昔布宁和托特罗定新型衍生物的设计、合成与活性

Design, synthesis and activity of novel derivatives of oxybutynin and tolterodine.

作者信息

Kaur Kirandeep, Aeron Shelly, Bruhaspathy Miriyala, Shetty Shankar J, Gupta Suman, Hegde Laxminarayan H, Silamkoti Arun D V, Mehta Anita, Chugh Anita, Gupta Jang B, Sarma P K S, Kumar Naresh

机构信息

Ranbaxy Research Laboratories, New Drug Discovery Research, Department of Medicinal Chemistry, Gurgaon 122 001, Haryana, India.

出版信息

Bioorg Med Chem Lett. 2005 Apr 15;15(8):2093-6. doi: 10.1016/j.bmcl.2005.02.036.

DOI:10.1016/j.bmcl.2005.02.036

PMID:15808475

Abstract

Novel derivatives of Tolterodine (1) and Oxybutynin (2) have been designed using conformationally restricted azabicyclics as replacement for open-chain amines. The synthesis and structure-activity relationships are presented.

摘要

已设计出用构象受限的氮杂双环化合物替代开链胺的托特罗定（1）和奥昔布宁（2）的新型衍生物。本文介绍了其合成方法及构效关系。