Fernández J Alonso, Tapia Lorena, Palomino M Angélica, Larrañaga Carmen, Peña Mónica, Jaramillo Héctor
Developmental Immunobiology Laboratory, Anatomy and Developmental Biology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Independencia 1027, Clasificador 7, Correo 7, Santiago, Chile.
Eur Cytokine Netw. 2005 Jan-Mar;16(1):35-40.
Adenovirus (ADV) and respiratory syncytial virus (RSV) are etiological agents of acute respiratory tract infection in infants. Long-term prognosis of ADV infection includes severe lung damage, bronchiectasis and hyperlucent lung, while RSV infection is associated with development of recurrent wheezing and subsequent asthma. These differences may be related to differences in the primary immune responses elicited by these viruses. In this paper, we investigated the type of cytokine responses and the magnitude of immune activation in ADV and RSV infections in infants. We examined plasma concentrations of interferon-gamma (IFN-gamma), interleukin-10 (IL-10), soluble interleukin-2 receptor (sCD25) and soluble tumor necrosis factor receptor II (sTNFR-II) in previously healthy infants during the acute phase of primary ADV infection (n = 21) and RSV infection (n = 68), and in uninfected controls (n = 44). In ADV-infected infants, IFN-gamma plasma levels were significantly higher than those observed in RSV cases and the control group (p < 0.05). RSV cases did not show any differences in IFN-gamma plasma levels compared to the other groups. sCD25 levels were significantly higher in ADV- and RSV-infected infants than in controls (p < 0.0001), and higher in ADV than in RSV cases (p < 0.05). sTNFR-II levels were significantly higher in RSV- and ADV-infected infants than in controls (p < 0.0001, p < 0.05, respectively), and higher in RSV than in ADV infection (p < 0.05). No significant differences were observed in IL-10 plasma concentrations between the three groups. These results indicate that ADV and RSV infections in infants differ significantly with regard to the magnitude of production of interferon-gamma and soluble immune activation markers sCD25 and sTNFR-II. These immunological differences may be involved in the different clinical outcomes associated with these viral infections.
腺病毒（ADV）和呼吸道合胞病毒（RSV）是婴儿急性呼吸道感染的病原体。ADV感染的长期预后包括严重的肺损伤、支气管扩张和肺透亮增强，而RSV感染与反复喘息及随后的哮喘发展有关。这些差异可能与这些病毒引发的初始免疫反应的差异有关。在本文中，我们研究了婴儿ADV和RSV感染中细胞因子反应的类型及免疫激活的程度。我们检测了先前健康的婴儿在原发性ADV感染（n = 21）和RSV感染（n = 68）急性期以及未感染对照组（n = 44）中血浆干扰素-γ（IFN-γ）、白细胞介素-10（IL-10）、可溶性白细胞介素-2受体（sCD25）和可溶性肿瘤坏死因子受体II（sTNFR-II）的浓度。在ADV感染的婴儿中，血浆IFN-γ水平显著高于RSV感染病例和对照组（p < 0.05）。与其他组相比，RSV感染病例的血浆IFN-γ水平无差异。ADV和RSV感染婴儿的sCD25水平显著高于对照组（p < 0.0001），且ADV感染婴儿的sCD25水平高于RSV感染病例（p < 0.05）。RSV和ADV感染婴儿的sTNFR-II水平显著高于对照组（分别为p < 0.0001和p < 0.05），且RSV感染婴儿的sTNFR-II水平高于ADV感染（p < 0.05）。三组间IL-10血浆浓度无显著差异。这些结果表明，婴儿ADV和RSV感染在干扰素-γ产生量以及可溶性免疫激活标志物sCD25和sTNFR-II方面存在显著差异。这些免疫差异可能与这些病毒感染相关的不同临床结局有关。
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