感染HIV-1会导致线粒体DNA减少。
Infection with HIV-1 induces a decrease in mtDNA.
作者信息
Casula Miriam, Bosboom-Dobbelaer Irene, Smolders Karlijn, Otto Sigrid, Bakker Margreet, de Baar Michel P, Reiss Peter, de Ronde Anthony
机构信息
International Antiviral Therapy Evaluation Center, Amsterdam, The Netherlands.
出版信息
J Infect Dis. 2005 May 1;191(9):1468-71. doi: 10.1086/429412. Epub 2005 Mar 25.
Cross-sectional studies have suggested that infection with human immunodeficiency virus (HIV) type 1 could reduce the mitochondrial DNA (mtDNA) content of blood cells. We investigated mtDNA content in peripheral blood mononuclear cells (PBMCs) obtained from 36 antiretroviral therapy-naive documented HIV-1 seroconverters, before and after seroconversion. mtDNA content statistically significantly decreased 1 year after seroconversion and showed a nonsignificant decrease during the subsequent 4 years. These findings confirm that infection with HIV-1 may, itself, reduce mtDNA content, at least within PBMCs. This could have implications for the subsequent development of mitochondrial toxicities associated with the use of nucleoside analogue reverse-transcriptase inhibitors.
横断面研究表明，感染1型人类免疫缺陷病毒（HIV）可能会降低血细胞中的线粒体DNA（mtDNA）含量。我们调查了36名初次接受抗逆转录病毒治疗且有记录的HIV-1血清转化者在血清转化前后外周血单个核细胞（PBMC）中的mtDNA含量。血清转化1年后，mtDNA含量在统计学上显著下降，在随后4年中呈非显著下降。这些发现证实，感染HIV-1本身可能会降低mtDNA含量，至少在PBMC中如此。这可能会对随后使用核苷类似物逆转录酶抑制剂时线粒体毒性的发生产生影响。
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