Zeppetella Giovambattista, Joel Simon P, Ribeiro Maria D C
Princess Alexandra Hospital NHS Trust, St. Clare Hospice, Hastingwood Road, Hastingwood, Essex CM17 9JX, UK.
Palliat Med. 2005 Mar;19(2):131-6. doi: 10.1191/0269216305pm985oa.
Several studies have reported that opioids applied topically to painful ulcers produce an analgesic effect. It is unknown whether these opioids (usually mixed with hydrogels) are stable and, if so, for how long. We investigated the stability of morphine sulphate and diamorphine hydrochloride, each mixed with intrasite gel at a concentration of 1.25 mg/mL. Samples were prepared in the laboratory and then stored in plastic containers in the dark, at room temperature, in conditions of normal day/night at room temperature, and at 4 degrees C. Aliquots were collected from each container over a 28-day period and analysed using HPLC. No known degradation products were measured in the morphine-intrasite gel mixture stored for up to 28 days, irrespective of the temperature and whether or not samples were exposed to light, suggesting that morphine remains stable. Diamorphine, breaks down to morphine and no other degradation products are measurable.
多项研究报告称，将阿片类药物局部应用于疼痛性溃疡可产生镇痛效果。目前尚不清楚这些阿片类药物（通常与水凝胶混合）是否稳定，如果稳定，能保持多长时间。我们研究了硫酸吗啡和盐酸二氢吗啡酮的稳定性，它们各自与安普贴凝胶以1.25mg/mL的浓度混合。样品在实验室制备，然后储存在塑料容器中，置于黑暗环境下，分别在室温、正常昼夜室温条件以及4℃下保存。在28天的时间里，从每个容器中取出等分试样，并用高效液相色谱法进行分析。在储存长达28天的吗啡 - 安普贴凝胶混合物中，无论温度如何以及样品是否暴露于光照下，均未检测到已知的降解产物，这表明吗啡保持稳定。二氢吗啡酮分解为吗啡，且未检测到其他降解产物。
