Ellis F H, Watkins E, Gibb S P, Heatley G J
Department of Thoracic and Cardiovascular Surgery, Lahey Clinic Medical Center, Burlington, Mass.
Eur J Cardiothorac Surg. 1992;6(2):86-9; discussion 90. doi: 10.1016/1010-7940(92)90080-h.
To determine the long-term clinical results after modified esophagomyotomy without an antireflux procedure for esophageal achalasia, the status of all patients undergoing this operation with a minimum follow-up time of 10 years was reviewed; 81 such patients were operated on between January 1970 and January 1981. Thirteen patients were lost to follow-up review permitting clinical evaluation during the past year of 68 patients (84%) observed for a median of 13.6 years. Fifty-nine patients (87%) were improved by operation; 90% of the patients who underwent a primary procedure were improved, whereas only 73% of patients undergoing reoperation benefited. Kaplan-Meier analysis of the results of all 81 patients disclosed an improvement rate of 98.5% at 5 years, 95.6% at 10 years, 85.8% at 15 years, and 67.3% at 20 years. When the level of improvement or lack thereof was analyzed, the percentage of excellent results decreased from 54% to 32% (P = 0.02). The percentage of good results remained the same, whereas fair or poor results together increased from 20% to 37% (P = 0.05). Neither age, sex, esophageal caliber, duration of symptoms, or previous therapy appeared to influence these results. We conclude that limited esophagomyotomy without an antireflux procedure results in persistent long-term improvement for the patient with esophageal achalasia. The level of improvement, however, decreases with the passage of time, presumably because of persistent disease in the body of the esophagus leading to impaired esophageal emptying in some patients and late reflux esophagitis in other patients owing to poor esophageal clearance.
为了确定改良食管肌层切开术(不附加抗反流手术)治疗贲门失弛缓症的长期临床效果,我们回顾了所有接受该手术且随访时间至少为10年的患者情况;1970年1月至1981年1月期间,共有81例此类患者接受了手术。13例患者失访,68例患者(84%)接受了临床评估,随访时间中位数为13.6年。59例患者(87%)术后病情改善;初次手术患者中有90%病情改善,而再次手术患者中只有73%受益。对所有81例患者的结果进行Kaplan-Meier分析显示,5年时改善率为98.5%,10年时为95.6%,15年时为85.8%,20年时为67.3%。分析改善程度或未改善情况时,优秀结果的百分比从54%降至32%(P = 0.02)。良好结果的百分比保持不变,而中等或差的结果合计从20%增至37%(P = 0.05)。年龄、性别、食管管径、症状持续时间或既往治疗似乎均不影响这些结果。我们得出结论,有限的食管肌层切开术(不附加抗反流手术)可使贲门失弛缓症患者获得持续的长期改善。然而,改善程度会随着时间推移而降低,推测是由于食管体部疾病持续存在,导致部分患者食管排空受损,而另一些患者因食管清除功能差出现晚期反流性食管炎。