Scherer David G, Brody Janet L, Annett Robert D, Hetter Jeanne, Roberts Laura Weiss, Cofrin Keely M W
College of Education, University of New Mexico, Albuquerque, NM 87131, USA.
J Pediatr. 2005 Apr;146(4):552-8. doi: 10.1016/j.jpeds.2004.12.024.
To examine the impact of financial compensation on pediatric asthma research participation decision-making and determine whether perceptions of fair compensation differed for parents and adolescents, lower and higher income participants, and compensation-informed and uninformed participants in minimal and above minimal risk research.
Adolescents (n = 36) with asthma and their parents reviewed 7 pediatric asthma research protocols, decided whether they would choose to participate, and provided estimates of "fair" compensation for their participation. Chi-square, analysis of variance, and analysis of covariance were used to determine the affects of compensation on participation and whether various respondents differed in the perceptions of fair compensation.
Financial compensation did not affect participation decisions. Estimates of fair compensation were lower for adolescents, lower income respondents, and participants who were naive about potential compensation. Fair compensation estimates were higher than actual compensation for minimal risk studies and lower for above minimal risk studies.
Financial compensation may be a minor consideration in pediatric research participation decision-making. Still, differences in how pediatric researchers and their prospective participants judge fair compensation create the potential for undue influence. Pediatric researchers should use caution when determining a reasonable financial compensation for research participation.
探讨经济补偿对儿童哮喘研究参与决策的影响，并确定在最低风险及以上风险研究中，父母与青少年、低收入与高收入参与者以及了解与不了解补偿情况的参与者对公平补偿的认知是否存在差异。
36名患有哮喘的青少年及其父母审阅了7项儿童哮喘研究方案，决定是否会选择参与，并对其参与的“公平”补偿进行估算。采用卡方检验、方差分析和协方差分析来确定补偿对参与的影响，以及不同受访者对公平补偿的认知是否存在差异。
经济补偿并未影响参与决策。青少年、低收入受访者以及对潜在补偿不知情的参与者对公平补偿的估算较低。对于最低风险研究，公平补偿估算高于实际补偿；对于高于最低风险的研究，公平补偿估算则低于实际补偿。
在儿童研究参与决策中，经济补偿可能是一个次要考虑因素。然而，儿童研究人员及其潜在参与者对公平补偿的判断差异可能会产生不当影响。儿童研究人员在确定合理的研究参与经济补偿时应谨慎行事。
