谷氨酸转运体：某些抗生素的意外靶点。
Glutamate transporter: an unexpected target for some antibiotics.
作者信息
Mao Jianren
出版信息
Mol Pain. 2005 Feb 9;1:5. doi: 10.1186/1744-8069-1-5.
Abstract
Glutamate transporter (GT) plays a major role in the mechanisms of glutamate homeostasis. Can this transporter system be a therapeutic target for glutamate-mediated neurological disorders? In January's edition of Nature, Rothstein et al (2005) reports that the most commonly used class of antibiotics (beta-lactam antibiotics) such as ceftriaxone promoted the expression of GLT1 and demonstrated a functional role in both in vitro and in vivo models of glutamate neurotoxicity. These findings indicate that positive promoters of GT expression may have a unique role in neuroprotection through regulating GT expression. This is also encouraging in search for new pharmacological tools for pain management.
摘要
谷氨酸转运体（GT）在谷氨酸稳态机制中起主要作用。这个转运体系统能否成为谷氨酸介导的神经疾病的治疗靶点呢？在1月份的《自然》杂志上，罗斯坦等人（2005年）报道，最常用的一类抗生素（β-内酰胺类抗生素），如头孢曲松，可促进GLT1的表达，并在谷氨酸神经毒性的体外和体内模型中显示出功能作用。这些发现表明，GT表达的正向促进剂可能通过调节GT表达在神经保护中发挥独特作用。这对于寻找疼痛管理的新药理工具也很有鼓舞作用。
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