含灰黄霉素的聚-ε-己内酯纳米颗粒的制备与表征

Preparation and characterization of poly-epsilon-caprolactone nanoparticles containing griseofulvin.

作者信息

Zili Zohra, Sfar Souad, Fessi Hatem

机构信息

Laboratoire de Pharmacie Galénique, Faculté de Pharmacie, Rue Avicenne, 5000 Monastir, Tunisie.

出版信息

Int J Pharm. 2005 Apr 27;294(1-2):261-7. doi: 10.1016/j.ijpharm.2005.01.020.

DOI:10.1016/j.ijpharm.2005.01.020

PMID:15814249

Abstract

Griseofulvin is an antifungal agent with poor solubility and low bioavailability. The aim of this work was to prepare poly-epsilon-caprolactone nanospheres and nanocapsules of griseofulvin by nanoprecipitation and to characterize them. Nanoparticles of griseofulvin were obtained with high encapsulation efficiency. The particle size was about 250-326 nm for nanospheres and 390-400 nm for nanocapsules. The dissolution rate of griseofulvin nanoparticles was higher than that of micronized griseofulvin therefore recourse to nanoencapsulation of griseofulvin should enhance its bioavailability and possibly its efficiency for the treatment of dermatomycosis.

摘要

灰黄霉素是一种溶解度差且生物利用度低的抗真菌剂。这项工作的目的是通过纳米沉淀法制备灰黄霉素的聚己内酯纳米球和纳米胶囊并对其进行表征。获得了具有高包封率的灰黄霉素纳米颗粒。纳米球的粒径约为250 - 326纳米，纳米胶囊的粒径约为390 - 400纳米。灰黄霉素纳米颗粒的溶解速率高于微粉化灰黄霉素，因此对灰黄霉素进行纳米包封应能提高其生物利用度，并可能提高其治疗皮肤真菌病的效果。