Yoneyama Hiroyuki, Matsuno Kenjiro, Matsushimaa Kouji
Department of Molecular Preventive Medicine & SORST, Graduate School of Medicine, The University of Tokyo, Japan.
Int J Hematol. 2005 Apr;81(3):204-7. doi: 10.1532/IJH97.04164.
The migration of dendritic cells (DCs) to lymph nodes (LNs) is pivotal to the establishment of the immune response. DCs have been proved to pass through the afferent lymphatic pathway to enter LNs from the peripheral tissues after they have scanned for self or nonself antigens. In response to danger signals, both myeloid and plasmacytoid DC precursors (mDC and pDC precursors) are rapidly mobilized into the circulation. mDC precursors are recruited to inflamed tissues in response to inflammatory chemokines and then remobilized to regional LNs in response to CCL21. In contrast, pDC precursors directly transmigrate to regional LNs via high endothelial venules in a CXCL9- and E-selectin-dependent manner. Such migration is largely dependent on systemic inflammatory reactions. After accumulating in the LNs through distinct trafficking pathways, DCs interact with lymphocytes temporally and spatially to establish effective immune responses. The inflammation-dependent, chemokine-driven property of DC precursor trafficking is a very sophisticated host defense system.
树突状细胞（DCs）向淋巴结（LNs）的迁移对于免疫反应的建立至关重要。已证明DCs在扫描自身或非自身抗原后，会通过传入淋巴途径从外周组织进入LNs。响应危险信号时，髓样和浆细胞样DC前体（mDC和pDC前体）都会迅速动员进入循环。mDC前体响应炎症趋化因子被招募到炎症组织，然后响应CCL21重新迁移到局部淋巴结。相比之下，pDC前体以CXCL9和E选择素依赖的方式通过高内皮静脉直接迁移到局部淋巴结。这种迁移很大程度上依赖于全身炎症反应。通过不同的运输途径在淋巴结中聚集后，DCs与淋巴细胞在时间和空间上相互作用，以建立有效的免疫反应。DC前体运输的炎症依赖性、趋化因子驱动特性是一种非常复杂的宿主防御系统。
