丹麦已知或疑似缺血性心脏病患者接受冠状动脉造影后的生存趋势：一项基于人群的随访研究，1992 - 2000年

Survival trends among Danish patients undergoing coronary angiography for known or suspected ischaemic heart disease: a population based follow up study, 1992-2000.

作者信息

Johnsen S P, Videbaek J, Pedersen L, Steffensen R, Videbaek R, Niemann T, Nielsen T T, Sørensen H T

机构信息

Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.

出版信息

Heart. 2006 Jan;92(1):27-31. doi: 10.1136/hrt.2004.053314. Epub 2005 Apr 6.

DOI:10.1136/hrt.2004.053314

PMID:15814596

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1860976/

Abstract

OBJECTIVE

To determine, from population based clinical data, changes in the survival of Danish patients examined by coronary angiography for known or suspected ischaemic heart disease (IHD) during the 1990s.

DESIGN

Follow up study.

SETTING

The departments of cardiology at Rigshospitalet, Copenhagen University Hospital, and Skejby Hospital, Aarhus University Hospital, Denmark.

PATIENTS

Patients with IHD (n = 7021) who underwent first time coronary angiography in 1992, 1996, or 2000.

MAIN OUTCOMES MEASURES

Three year survival was compared between cohorts and with that of the general population. Cox proportional hazards regression was used to estimate mortality ratios adjusted for differences in patient characteristics.

RESULTS

Survival improved substantially--for example, adjusted mortality ratio was 0.69 (95% confidence interval (CI) 0.55 to 0.87) when comparing patients from 2000 with patients from 1992. The absolute standardised survival rates after three years of follow up were 87.1% (95% CI 85.4% to 88.8%), 89.9% (95% CI 88.5% to 91.3%), and 91.2% (95% CI 90.3% to 92.1%) among patients examined in 1992, 1996, and 2000, respectively. The improvement was not explained by the improvement in overall survival in the general population during the study period.

CONCLUSIONS

The survival of Danish patients with known or suspected IHD appears to have improved substantially during the 1990s.

摘要

目的

根据基于人群的临床数据，确定20世纪90年代丹麦因已知或疑似缺血性心脏病（IHD）接受冠状动脉造影检查的患者生存率的变化。

设计

随访研究。

地点

丹麦哥本哈根大学医院里格霍斯皮塔尔心血管科以及奥胡斯大学医院斯基比医院。

患者

1992年、1996年或2000年首次接受冠状动脉造影检查的IHD患者（n = 7021）。

主要结局指标

比较各队列之间以及与普通人群的三年生存率。采用Cox比例风险回归来估计针对患者特征差异进行调整后的死亡率比值。

结果

生存率显著提高——例如，将2000年的患者与1992年的患者进行比较时，调整后的死亡率比值为0.69（95%置信区间（CI）0.55至0.87）。在1992年、1996年和2000年接受检查的患者中，随访三年后的绝对标准化生存率分别为87.1%（95% CI 85.4%至88.8%）、89.9%（95% CI 88.5%至91.3%）和91.2%（95% CI 90.3%至92.1%）。该改善不能用研究期间普通人群总体生存率的提高来解释。