Shimizu T, Hizawa N, Honda A, Zhao Y, Abe R, Watanabe H, Nishihira J, Nishimura M, Shimizu H
Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Genes Immun. 2005 Jun;6(4):285-9. doi: 10.1038/sj.gene.6364191.
We have demonstrated that serum macrophage migration inhibitory factor (MIF) was significantly elevated in patients with extensive alopecia areata (AA). Recently, functional polymorphisms have been identified in the MIF promoter region. To address the functional and prognostic relevance of the -173G/C and -794[CATT]5-8 repeat polymorphisms in MIF genes in patients with extensive AA, 113 patients with extensive AA and 194 healthy controls were genotyped. We found that MIF-173C was a risk factor for early onset (<20 years) of extensive AA (odds ratio for GC heterozygotes with -173G/C was 4.88 (95% CI, 2.04-11.8), P=0.00038; odds ratio for CC homozygotes with -173G/C was 10.42 (95% CI, 2.56-43.5), P=0.0011). We found no statistically significant differences in the genotype frequencies of the -794[CATT]5-8 repeat polymorphism and extensive AA. These results suggest that polymorphisms within the MIF-173C allele confer an increased risk of susceptibility to the extensive forms of AA, especially with an early onset of disease. MIF is therefore suggested to be closely implicated in the pathogenesis of the more extensive forms of AA.
我们已经证明，广泛性斑秃（AA）患者血清巨噬细胞移动抑制因子（MIF）显著升高。最近，在MIF启动子区域发现了功能多态性。为了探讨MIF基因中-173G/C和-794[CATT]5-8重复多态性在广泛性AA患者中的功能和预后相关性，对113例广泛性AA患者和194例健康对照进行了基因分型。我们发现，MIF-173C是广泛性AA早发（<20岁）的危险因素（-173G/C的GC杂合子优势比为4.88（95%CI，2.04-11.8），P=0.00038；-173G/C的CC纯合子优势比为10.42（95%CI，2.56-43.5），P=0.0011）。我们发现-794[CATT]5-8重复多态性的基因型频率与广泛性AA之间无统计学显著差异。这些结果表明，MIF-173C等位基因内的多态性增加了患广泛性AA的易感性风险，尤其是疾病早发时。因此，提示MIF与更广泛形式的AA发病机制密切相关。
