Handzel Z T, Dolfin Z, Levin S, Altman Y, Hahn T, Trainin N, Gadot N
Pediatr Res. 1979 Jul;13(7):803-6. doi: 10.1203/00006450-197907000-00002.
Cellular immune functions of nine Down's syndrome patients and of nine was Ataxia telangiectasia vs. nine normal children and nine cord bloods, were evaluated using in vitro assays of peripheral blood lymphocytes. The in vitro assays included E rosette formation, antilymphocytic cytotoxicity by an antithymic antiserum and leukocyte migration inhibition factor (LIF) production. The mitogens and antigens used were phytohemagglutinin, purified protein derivative, and monilia antigen. The effect of a thymic hormone (THF) on these parameters was evaluated and it was administered therapeutically to three Down's syndrome patients and to two patients with Ataxia telangiectasia. Most deficient T-cell functions were reversed to normal after incubation of the lymphocytes with THF, or after THF therapeutic administration. In two Down's syndrome cases, the clinical course was not altered by THF administration, while one seemed to benefit from it markedly. One of the Atactic patients recovered from a severe viral infection, while the other died from intractable bronchopneumonia.
采用外周血淋巴细胞体外检测法，对9名唐氏综合征患者、9名共济失调毛细血管扩张症患者、9名正常儿童和9份脐血的细胞免疫功能进行了评估。体外检测包括E玫瑰花结形成、抗胸腺抗血清介导的抗淋巴细胞细胞毒性以及白细胞迁移抑制因子（LIF）的产生。所用的促有丝分裂原和抗原有植物血凝素、纯化蛋白衍生物和念珠菌抗原。评估了一种胸腺激素（THF）对这些参数的影响，并对3名唐氏综合征患者和2名共济失调毛细血管扩张症患者进行了治疗性给药。淋巴细胞与THF孵育后，或THF治疗性给药后，大多数缺陷的T细胞功能恢复正常。在2例唐氏综合征病例中，THF给药未改变临床病程，而1例似乎明显受益。1例共济失调患者从严重病毒感染中康复，另1例死于难治性支气管肺炎。
