Leucocyte migration in presence of leukaemia-associated antigens in children with Down's syndrome.

The effect of leukaemia-associated antigens prepared from leukaemic lymphoblasts and myeloblasts has been studied on the migration of peripheral leucocytes obtained from children with Down's syndrome. Membrane extract from leukaemic lymphoblasts had no effect, while that from leukaemic myeloblasts was slightly inhibitory, i.e. it was "recognized" as antigen by the lymphocytes of children with Downs syndrome.