中国宣威地区DNA碱基切除修复基因APEX1和XRCC1的多态性与肺癌风险
Polymorphisms in the DNA base excision repair genes APEX1 and XRCC1 and lung cancer risk in Xuan Wei, China.
作者信息
Shen Min, Berndt Sonja I, Rothman Nathaniel, Mumford Judy L, He Xingzhou, Yeager Meredith, Welch Robert, Chanock Stephen, Keohavong Phouthone, Donahue Mark, Zheng Tongzhang, Caporaso Neil, Lan Qing
机构信息
Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland 20892-7240, USA.
出版信息
Anticancer Res. 2005 Jan-Feb;25(1B):537-42.
The lung cancer mortality rate in Xuan Wei is among the highest in China and has been causally attributed to high exposure to indoor smoky coal emissions, which contain high levels of PAHs and can lead to modified bases. We studied genetic polymorphisms in four DNA base excision repair genes in a population-based case-control study in Xuan Wei with 122 lung cancer cases and 122 controls. Homozygous carriers of the APEX1 148Glu variant had an increased risk (OR, 2.13; 95% CI, 0.96-4.74), whereas persons with the XRCC1 399Gln allele had a decreased risk (OR, 0.60; 95% CI, 0.35-1.02) of lung cancer compared with wild-type carriers. Subjects with both at-risk genotypes (APEX1 Glu148Glu and XRCC1 Arg399Arg) had a higher risk of lung cancer (OR: 3.34; 95% CI: 1.16-9.67). We found genetic variants in APEX1 and XRCC1 may alter the risk of lung cancer in a special population in China.
宣威的肺癌死亡率位居中国前列，其病因被认为是长期暴露于室内煤烟排放物中，这些排放物含有高浓度的多环芳烃，并可导致碱基修饰。我们在宣威进行了一项基于人群的病例对照研究，对122例肺癌病例和122例对照者的四个DNA碱基切除修复基因的遗传多态性进行了研究。携带APEX1 148Glu变异的纯合子患癌风险增加（比值比，2.13；95%置信区间，0.96 - 4.74），而携带XRCC1 399Gln等位基因的人患肺癌的风险低于野生型携带者（比值比，0.60；95%置信区间，0.35 - 1.02）。同时具有两种风险基因型（APEX1 Glu148Glu和XRCC1 Arg399Arg）的受试者患肺癌的风险更高（比值比：3.34；95%置信区间：1.16 - 9.67）。我们发现APEX1和XRCC1中的基因变异可能会改变中国某一特定人群的肺癌风险。
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