Fattori Rossella, Tricoci Pierluigi, Russo Vincenzo, Lovato Luigi, Bacchi-Reggiani Letizia, Gavelli Giampaolo, Branzi Angelo, Boriani Giuseppe
Department of Radiology, University Hospital S. Orsola-Malpighi, Bologna, Italy.
J Cardiovasc Electrophysiol. 2005 Mar;16(3):256-61. doi: 10.1046/j.1540-8167.2004.40498.x.
Arrhythmogenic right ventricular dysplasia (ARVD) is a heart muscle disorder in which the pathological substrate is a fatty or fibro-fatty replacement of the right ventricular (RV) myocardium.
Magnetic resonance imaging (MRI) studies were performed in 10 patients with arrhythmogenic right ventricular dysplasia and in 24 matched controls in order to assess right ventricular epicardial/intramyocardial fatty tissue mass, RV myocardial mass, and RV functional parameters. Functional abnormalities were found in all ARVD cases. Patients with ARVD showed increased fatty tissue compared to controls (8.2 +/- 4 g vs. 2.0 +/- 1.0 g; P = 0.001), whereas no significant differences were found in RV myocardial mass (29.5 +/- 9.2 g vs. 23.2 +/- 6.7 g; P = NS). A correlation coefficient between 0.87 and 0.97 was found for repeated measurements.
Quantification of fatty tissue with MRI is feasible and constitutes an objective method for differentiating normal from pathological conditions. This approach may lead to a complete diagnostic assessment of ARVD with the potential application for monitoring the evolution of the disease.
致心律失常性右室心肌病（ARVD）是一种心肌疾病，其病理基础是右心室（RV）心肌被脂肪或纤维脂肪组织替代。
对10例致心律失常性右室心肌病患者和24例匹配的对照者进行了磁共振成像（MRI）研究，以评估右心室心外膜/心肌内脂肪组织量、右室心肌质量和右室功能参数。所有ARVD病例均发现功能异常。与对照组相比，ARVD患者的脂肪组织增加（8.2±4g对2.0±1.0g；P=0.001），而右室心肌质量无显著差异（29.5±9.2g对23.2±6.7g；P=无显著性差异）。重复测量的相关系数在0.87至0.97之间。
用MRI定量脂肪组织是可行的，是区分正常与病理状态一种客观方法。这种方法可能会对ARVD进行全面的诊断评估，并有可能用于监测疾病的进展。
