Komater Victoria A, Buckley Michael J, Browman Kaitlin E, Pan Jia Bao, Hancock Arthur A, Decker Michael W, Fox Gerard B
Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, AP9A, D4N5, Abbott Park, IL 60064, USA.
Behav Brain Res. 2005 Apr 30;159(2):295-300. doi: 10.1016/j.bbr.2004.11.008. Epub 2004 Dec 10.
Despite the well-described attention and short-term memory enhancing effects of H3 receptor antagonists, and evidence to suggest a close relationship between central histaminergic and cholinergic systems, there is a paucity of evidence for a role for H3 receptor blockade in spatial learning. To address this, we investigated two H3 receptor antagonists in a visual discrimination water maze in rats, and in a Barnes circular maze in mice. Thioperamide and ciproxifan significantly attenuated a scopolamine-induced deficit in the water maze task, while only ciproxifan showed a modest attenuation in the Barnes maze. Taken together, these data suggest a role for H3 receptors in spatial learning that appears to be task-dependent.
