Miyazaki S, Imaizumi M, Onodera K
Biology Laboratory, R. & D. Div., Yamasa Corporation, Choshi, Japan.
Life Sci. 1995;57(23):2137-44. doi: 10.1016/0024-3205(95)02206-x.
We examined the effects of thioperamide and (R)-alpha-methylhistamine, a histamine H3-receptor antagonist and an agonist, respectively, on a scopolamine-induced learning deficit using an elevated plus-maze test in mice. Thioperamide alone slightly improved the learning deficit induced by scopolamine, and pretreatment with zolantidine, a histamine H2-receptor antagonist, significantly enhanced the effect of thioperamide in this test. (R)-alpha-Methylhistamine, pyrilamine, ketotifen, terfenadine, and zolantidine alone at the doses tested had no effect. Moreover, the improvement by thioperamide plus zolantidine was antagonized by pretreatment with histamine H1-receptor antagonists such as pyrilamine or ketotifen, but not by terfenadine. Thus, thioperamide improved the scopolamine-induced learning deficit through central histamine H1 receptors in mice. The present results supported the hypothesis that histamine may play an important role in learning and memory.
我们分别使用高架十字迷宫试验，研究了组胺H3受体拮抗剂硫代酰胺和激动剂（R）-α-甲基组胺对东莨菪碱诱导的小鼠学习缺陷的影响。单独使用硫代酰胺可轻微改善东莨菪碱诱导的学习缺陷，并且用组胺H2受体拮抗剂佐兰替丁预处理可显著增强硫代酰胺在该试验中的效果。单独使用（R）-α-甲基组胺、吡苄明、酮替芬、特非那定和佐兰替丁在测试剂量下均无作用。此外，硫代酰胺加佐兰替丁的改善作用被组胺H1受体拮抗剂如吡苄明或酮替芬预处理所拮抗，但不被特非那定拮抗。因此，硫代酰胺通过小鼠中枢组胺H1受体改善了东莨菪碱诱导的学习缺陷。目前的结果支持组胺可能在学习和记忆中起重要作用这一假说。
