Hong Theodore S, Tomé Wolfgang A, Harari Paul M
Department of Human Oncology, University of Wisconsin Medical School, Madison, WI, USA.
Curr Opin Oncol. 2005 May;17(3):231-5. doi: 10.1097/01.cco.0000158734.84099.38.
Intensity-modulated radiation therapy (IMRT) represents a potentially significant new advance in the radiotherapeutic treatment of head and neck cancer patients. The capacity of IMRT to produce highly conformal dose distributions affords the opportunity to decrease the spectrum of toxicities associated with head and neck radiation. This review updates recent advances regarding the use of this emerging technology.
Mature clinical data demonstrating head and neck IMRT safety and efficacy remain relatively limited to date. Recent publications have sought to clarify target selection and delineation. Refinements in target design driven by clinical outcomes are beginning to emerge. Technical aspects of IMRT delivery such as the impact of daily set-up variation, planning methods, and optimal fractionation regimens are progressing.
Stepwise refinement in the practice of IMRT for head and neck cancer patients is advancing worldwide. However, mature clinical data remains relatively limited and specific aspects regarding the practice of head and neck IMRT remain heterogeneous.
调强放射治疗（IMRT）是头颈癌患者放射治疗中一项潜在的重大新进展。IMRT产生高度适形剂量分布的能力为减少与头颈放疗相关的毒性谱提供了机会。本综述更新了关于这项新兴技术应用的最新进展。
迄今为止，证明头颈IMRT安全性和有效性的成熟临床数据仍然相对有限。最近的出版物试图阐明靶区的选择和勾画。由临床结果驱动的靶区设计改进已开始出现。IMRT实施的技术方面，如每日摆位变化的影响、计划方法和最佳分割方案等正在不断发展。
全球范围内，头颈癌患者IMRT实践的逐步完善正在推进。然而，成熟的临床数据仍然相对有限，头颈IMRT实践的具体方面仍存在差异。
