Kano K, Ichimura T
First Department of Pediatrics, Dokkyo University School of Medicine, Tochigi, Japan.
Clin Chem. 1992 May;38(5):624-7.
For treatment and prognostic evaluation of patients with measles, it is important to determine the source of the increase in serum alpha-hydroxybutyrate dehydrogenase (HBD; EC 1.1.99.6). Here we measured HBD and L-lactate dehydrogenase (LD; 1.1.1.27) activities in the serum of 18 children with measles and in 18 age-matched control patients with bronchopneumonia. HBD and LD activities in the measles patients were significantly higher than those in control subjects (P less than 0.001). The HBD/LD ratio in the measles patients two to three days after the onset of rash was significantly lower than that in control subjects (P less than 0.001). The low HBD/LD ratio was similar to the ratio found in lymphocytes. The number of peripheral lymphocytes decreased markedly after the onset of rash. Our results suggest that increased serum HBD and LD activity is common in measles infection and that the increase originates from the destruction of infected lymphocytes rather than from myocardiac injury.
对于麻疹患者的治疗和预后评估，确定血清α-羟丁酸脱氢酶（HBD；EC 1.1.99.6）升高的来源很重要。在此，我们检测了18例麻疹患儿以及18例年龄匹配的支气管肺炎对照患者血清中的HBD和L-乳酸脱氢酶（LD；1.1.1.27）活性。麻疹患者的HBD和LD活性显著高于对照受试者（P＜0.001）。出疹后两到三天，麻疹患者的HBD/LD比值显著低于对照受试者（P＜0.001）。低HBD/LD比值与淋巴细胞中的比值相似。出疹后外周淋巴细胞数量显著减少。我们的结果表明，血清HBD和LD活性升高在麻疹感染中很常见，且这种升高源于受感染淋巴细胞的破坏而非心肌损伤。
