Sheppard Richard, Behlouli Hassan, Richard Hugues, Pilote Louise
Sir Mortimer B. Davis/Jewish General Hospital, Montreal, Quebec, Canada.
Am J Cardiol. 2005 Apr 15;95(8):955-9. doi: 10.1016/j.amjcard.2004.12.033.
This study assessed whether a gender gap exists in therapy, procedure use, and outcomes in patients who have a new diagnosis of congestive heart failure (CHF) at the population level. The Quebec hospital discharge database was linked with the physician and drug claims databases to identify a cohort of patients who had a diagnosis of CHF (code 428 in the International Classification of Diseases, Ninth Revision) between January 1998 and December 2002. There were 16,017 men and 16,622 women. Women who had CHF were older (78 +/- 11 vs 73 +/- 11 years, p <0.001), had more hypertension (41% vs 28%, p <0.001) and hyperlipidemia (18% vs 14%, p <0.001) but less frequent myocardial infarction (19% vs 25%, p <0.001). Women were less likely to see a cardiologist (30% vs 34%, p <0.001) and required a longer hospital stay (12.0 +/- 14.8 vs 10.6 +/- 13.3 days, p <0.001). During the first year after a first CHF hospitalization, women were less like to have an assessment of left ventricular function (61% vs 65%, p <0.001), diagnostic cardiac catheterization (11% vs 15%, p <0.001), and revascularization procedure (4% vs 6%, p <0.001). Women were less likely to be prescribed an angiotensin-converting enzyme inhibitor (60% vs 66%) and more likely to be prescribed a beta blocker (38% vs 34%). Women and men had similar yearly numbers of rehospitalizations for CHF (1.4 +/- 1.0 vs 1.5 +/- 1.0) and emergency room visits (1.7 +/- 1.2 vs 1.8 +/- 1.3). The adjusted risk of death was minimally higher in men than in women (hazard ratio 1.06, 95% confidence interval 1.03 to 1.1, p <0.01). Thus, despite less frequent cardiologist assessment, fewer cardiac-related procedures, and less frequent use of standard medical therapy, clinical outcomes in women and men who had CHF were similar.
本研究评估了在总体人群中,新诊断为充血性心力衰竭(CHF)的患者在治疗、手术使用及治疗结果方面是否存在性别差异。魁北克医院出院数据库与医师和药物报销数据库相链接,以确定1998年1月至2002年12月期间诊断为CHF(国际疾病分类第九版中的代码428)的患者队列。其中有16017名男性和16622名女性。患有CHF的女性年龄更大(78±11岁对73±11岁,p<0.001),高血压(41%对28%,p<0.001)和高脂血症(18%对14%,p<0.001)的发生率更高,但心肌梗死发生率更低(19%对25%,p<0.001)。女性看心脏病专家的可能性更小(30%对34%,p<0.001),住院时间更长(12.0±14.8天对10.6±13.3天,p<0.001)。在首次CHF住院后的第一年,女性接受左心室功能评估(61%对65%,p<0.001)、诊断性心导管检查(11%对15%,p<0.001)和血运重建手术(4%对6%,p<0.001)的可能性更小。女性接受血管紧张素转换酶抑制剂治疗的可能性更小(60%对66%),而接受β受体阻滞剂治疗的可能性更大(38%对34%)。女性和男性因CHF再次住院的年次数(1.4±1.0次对1.5±1.0次)和急诊就诊次数(1.7±1.2次对1.8±1.3次)相似。校正后的死亡风险男性略高于女性(风险比1.06,95%置信区间1.03至1.1,p<0.01)。因此,尽管女性看心脏病专家的频率较低,心脏相关手术较少,标准药物治疗的使用频率也较低,但患有CHF的女性和男性的临床结果相似。