Marković M, Majkić-Singh N, Ignjatović S, Singh S
Institute of Medical Biochemistry, Military Medical Academy, Belgrade, Serbia.
Int J Lab Hematol. 2007 Oct;29(5):341-6. doi: 10.1111/j.1365-2257.2006.00875.x.
Ferritin concentration, as a parameter of iron status that is commonly used in the diagnosis of iron deficiency anaemia (IDA), often has limited values if the iron deficiency is accompanied by inflammatory disease. This study evaluated the value of reticulocyte haemoglobin content (CHr) and soluble transferrin receptor-ferritin index (sTfR/F) in the diagnosis of IDA and differential diagnosis of IDA and anaemia of chronic disease. The study included 66 nonanaemic individuals as controls, 86 patients with IDA divided into noninflammatory and inflammatory subgroups, and 32 patients with anaemia of chronic disease. Blood count, iron, transferrin saturation, total iron binding capacity, ferritin, C-reactive protein, sTfR and CHr were determined. Receiver operator characteristic curve analysis showed very high discriminating power for CHr, soluble transferrin receptor (sTfR) and sTfR/F in the diagnosis of IDA. In patients with anaemia of chronic disease these parameters showed no significant difference from the control. CHr and sTfR enabled recognition of iron deficiency and were not affected by acute phase reaction. They are sensitive markers of body iron status with additional value to conventional tests for the detection of iron deficiency.
铁蛋白浓度作为常用于诊断缺铁性贫血（IDA）的铁状态参数，如果缺铁伴有炎症性疾病，其价值往往有限。本研究评估了网织红细胞血红蛋白含量（CHr）和可溶性转铁蛋白受体 - 铁蛋白指数（sTfR/F）在IDA诊断以及IDA与慢性病贫血鉴别诊断中的价值。该研究纳入了66名非贫血个体作为对照组，86例IDA患者分为非炎症和炎症亚组，以及32例慢性病贫血患者。测定了血细胞计数、铁、转铁蛋白饱和度、总铁结合力、铁蛋白、C反应蛋白、sTfR和CHr。受试者工作特征曲线分析显示，CHr、可溶性转铁蛋白受体（sTfR）和sTfR/F在IDA诊断中具有很高的鉴别能力。在慢性病贫血患者中，这些参数与对照组无显著差异。CHr和sTfR能够识别缺铁，且不受急性期反应影响。它们是机体铁状态的敏感标志物，对检测缺铁的传统检查具有附加价值。
