Cadet E, Gadenne M, Capron D, Rochette J
Service de génétique moléculaire médicale et UPRES EA 2629, CHU d'Amiens, université de Picardie-Jules-Verne, 3, rue des Louvels, 80036 Amiens cedex, France.
Rev Med Interne. 2005 Apr;26(4):315-24. doi: 10.1016/j.revmed.2004.09.024. Epub 2004 Dec 7.
Advances towards the understanding of gene regulation and protein function recently discovered through iron metabolism disorders are the subject of this review.
Within a few years the discovery of genes that determine heritable defects of cellular iron uptake or regulation in mice as in humans have provided new insights for investigation into iron metabolism pathways.
It is still unclear how connections are made between new proteins in iron uptake, trafficking and regulation of iron homeostasis. Gene expression studies using microarrays technology in different iron conditions should help to explore iron homeostasis further.
本文综述了近期通过铁代谢紊乱在基因调控和蛋白质功能理解方面取得的进展。
在短短几年内，在小鼠和人类中发现了决定细胞铁摄取或调节的遗传性缺陷的基因，这为研究铁代谢途径提供了新的见解。
目前仍不清楚铁摄取、转运和铁稳态调节中的新蛋白质之间是如何建立联系的。利用微阵列技术在不同铁条件下进行基因表达研究应有助于进一步探索铁稳态。
