Donovan Adriana, Roy Cindy N, Andrews Nancy C
Children's Hospital Boston, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.
Physiology (Bethesda). 2006 Apr;21:115-23. doi: 10.1152/physiol.00052.2005.
Iron is an essential element that is toxic when it accumulates in excess. Intricate regulatory mechanisms have evolved to maintain iron homeostasis within cells and between different tissues of complex organisms. This review discusses the proteins involved in iron transport and storage and their regulation in health and disease.
铁是一种必需元素，但过量积累时具有毒性。复杂的生物进化出了精密的调节机制，以维持细胞内以及复杂生物体不同组织之间的铁稳态。本综述讨论了参与铁运输和储存的蛋白质及其在健康和疾病中的调节。
