系统性红斑狼疮中针对不均一核糖核蛋白A1的抗体：与雷诺现象和食管动力障碍的临床关联

Antibodies to hn-RNP protein A1 in systemic lupus erythematosus: clinical association with Raynaud's phenomenon and esophageal dysmotility.

作者信息

Montecucco C, Caporali R, Cobianchi F, Negri C, Astaldi-Ricotti G C

机构信息

Istituto di Patologia Medica, University of Pavia, Italy.

出版信息

Clin Exp Rheumatol. 1992 May-Jun;10(3):223-7.

PMID:1582066

Abstract

Antibodies to recombinant hn-RNP protein A1 were found by ELISA in sera from 26 out of 67 unselected patients with systemic lupus erythematosus. A higher number of anti-A1 positive patients had Raynaud's phenomenon (50% vs 7%) and esophageal dysmotility (42% vs 5%) than the anti-A1 negative patients. All 8 patients with both Raynaud's phenomenon and esophageal dysmotility had a positive anti-A1 assay. No association was found with other clinical findings, nor with disease activity and treatment regimes. Anti-A1 antibodies did not correlate with anti-RNP and anti-Sm antibodies, which were present in 30% and 12% of the anti-A1 positive cases and in 22% and 7% of the anti-A1 negative cases, respectively. Our results indicate that antibodies to hn-RNP protein A1 may be associated with a subset of SLE patients with clinical features overlapping those of progressive systemic sclerosis and quite distinct from the group identified by anti-RNP antibodies.

摘要

通过酶联免疫吸附测定法（ELISA）发现，在67例未经挑选的系统性红斑狼疮患者中，有26例患者的血清中存在针对重组核不均一核糖核蛋白（hn-RNP）A1蛋白的抗体。与抗A1阴性患者相比，抗A1阳性患者出现雷诺现象（50% 比7%）和食管动力障碍（42% 比5%）的人数更多。所有8例同时出现雷诺现象和食管动力障碍的患者抗A1检测均为阳性。未发现与其他临床发现、疾病活动度及治疗方案存在关联。抗A1抗体与抗RNP及抗Sm抗体无相关性，抗A1阳性病例中分别有30%和12%存在抗RNP和抗Sm抗体，抗A1阴性病例中分别有22%和7%存在抗RNP和抗Sm抗体。我们的结果表明，针对hn-RNP A1蛋白的抗体可能与一部分系统性红斑狼疮患者相关，这些患者的临床特征与进行性系统性硬化症有重叠，且与抗RNP抗体所识别的群体明显不同。