系统性红斑狼疮与雷诺现象。
Systemic lupus erythematosus and Raynaud's phenomenon.
作者信息
Heimovski Flavia Emilie, Simioni Juliana A, Skare Thelma Larocca
机构信息
Faculdade Evangélica do Paraná, Curitiba, PR, Brazil.
出版信息
An Bras Dermatol. 2015 Nov-Dec;90(6):837-40. doi: 10.1590/abd1806-4841.20153881.
BACKGROUND
Patients with systemic lupus erythematosus seem to belong to different serological and clinical subgroups of the disease. Genetic background can cause the appearance of these subgroups.
OBJECTIVE
To determine whether Brazilian patients who have systemic lupus erythematosus and Raynaud's phenomenon differ from those who do not.
METHODS
Retrospective analysis of 373 medical records of systemic lupus erythematosus patients studied for demographic, clinical and serological data. A comparative analysis was performed of individuals with and without RP.
RESULTS
There was a positive association between Raynaud's phenomenon and age at diagnosis (p=0.02), presence of anti-Sm (p=0.01) antibodies and anti-RNP (p<0.0001). Furthermore, a negative association was found between Raynaud's phenomenon and hemolysis (p=0.01), serositis (p=0.01), glomerulonephritis (p=0.0004) and IgM aCL (p=0.004) antibodies.
CONCLUSION
Raynaud's phenomenon patients appear to belong to a systemic lupus erythematosus subset with a spectrum of clinical manifestations located in a more benign pole of the disease.
背景
系统性红斑狼疮患者似乎属于该疾病不同的血清学和临床亚组。遗传背景可导致这些亚组的出现。
目的
确定患有系统性红斑狼疮和雷诺现象的巴西患者与未患该现象的患者是否存在差异。
方法
回顾性分析373例系统性红斑狼疮患者的病历，研究其人口统计学、临床和血清学数据。对有和没有雷诺现象的个体进行比较分析。
结果
雷诺现象与诊断时的年龄（p=0.02）、抗Sm抗体（p=0.01）和抗RNP抗体（p<0.0001）的存在呈正相关。此外，雷诺现象与溶血（p=0.01）、浆膜炎（p=0.01）、肾小球肾炎（p=0.0004）和IgM aCL抗体（p=0.004）呈负相关。
结论
雷诺现象患者似乎属于系统性红斑狼疮的一个亚组，其临床表现谱位于该疾病更良性的一端。
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