Sumich Alex, Chitnis Xavier A, Fannon Dominic G, O'Ceallaigh Séamus, Doku Victor C, Faldrowicz Abi, Sharma Tonmoy
BIAU, Biostatistics and Computing, Institute of Psychiatry, London, UK.
Biol Psychiatry. 2005 Apr 15;57(8):947-50. doi: 10.1016/j.biopsych.2004.12.041.
Schizophrenia may involve dysfunction to primary auditory, speech, and language processes governed by the superior temporal gyrus (STG). These processes are implicated in hallucinations, delusions, and thought disorder. The current study explored the relationship between unreality symptoms (hallucinations and delusions) and specific STG substructures, including Heschl's gyrus (HG) and planum temporale (PT).
Twenty-five right-handed men within their first episode of psychosis were assessed using the Positive and Negative Syndrome Scale (PANSS) for the presence of hallucinations and delusional behavior (a composite score of delusions, grandiosity, suspiciousness, and unusual thought content). T1-weighted magnetic resonance imaging (MRI) scans were acquired using a 1.5 Tesla scanner. Stereological measurements of HG and PT volume were obtained. Linear regression methods explored the relationship between regional volumes and symptoms.
Reductions in left HG were associated with hallucinations and delusions. Increases in left PT were associated with delusional behavior.
Current results implicate HG dysfunction in unreality symptoms in men with recent-onset schizophrenia.
精神分裂症可能涉及由颞上回（STG）支配的初级听觉、言语和语言过程的功能障碍。这些过程与幻觉、妄想和思维障碍有关。当前研究探讨了虚幻症状（幻觉和妄想）与特定的颞上回亚结构之间的关系，包括颞横回（HG）和颞平面（PT）。
对25名首次发作精神病的右利手男性，使用阳性和阴性症状量表（PANSS）评估幻觉和妄想行为的存在情况（妄想、夸大、猜疑和异常思维内容的综合评分）。使用1.5特斯拉扫描仪进行T1加权磁共振成像（MRI）扫描。获得了颞横回和颞平面体积的体视学测量值。采用线性回归方法探讨区域体积与症状之间的关系。
左侧颞横回体积减小与幻觉和妄想有关。左侧颞平面体积增加与妄想行为有关。
当前结果表明近期发病的男性精神分裂症患者的虚幻症状与颞横回功能障碍有关。
