Morin Mathieu, Bellehumeur Christian, Therriault Marie-Josée, Metz Christine, Maheux Rodolphe, Akoum Ali
Laboratoire d'Endocrinologie de la Reproduction, Centre de Recherche, Hôpital Saint-François d'Assise, Centre Hospitalier Universitaire de Québec (CHUQ), Faculté de Médecine, Université Laval, 10 rue de l'Espinay, Québec, PQ, Canada G1L 3L5.
Fertil Steril. 2005 Apr;83(4):865-72. doi: 10.1016/j.fertnstert.2004.10.039.
To evaluate the concentrations of macrophage migration inhibitory factor (MIF) in the peripheral blood of normal women and patients with endometriosis.
Retrospective study using ELISA to measure peripheral blood MIF.
Gynecology clinic and human reproduction research laboratory.
PATIENT(S): Thirty-eight normal women and 55 women with endometriosis.
INTERVENTION(S): Peripheral blood samples were obtained a few days before laparoscopy.
MAIN OUTCOME MEASURE(S): The MIF concentrations in blood serum.
RESULT(S): This current study showed a 364% increase in MIF concentrations in women with endometriosis as compared to normal women. A significant increase was seen in endometriosis stages I-II, but a more marked increase was observed in the more advanced stages of the disease (III-IV). Both fertile and infertile women with endometriosis had higher levels of MIF than normal controls, but the difference was more significant in infertile women with endometriosis. Women with endometriosis with no pelvic pain had higher levels of MIF than normal controls, but a more significant increase in MIF levels was observed in women with endometriosis reporting pelvic pain.
CONCLUSION(S): This study showed a marked increase in MIF concentrations in the peripheral blood of women with endometriosis and a relationship with disease progress, and suggests that MIF may be involved in endometriosis-related pain and infertility.
评估正常女性和子宫内膜异位症患者外周血中巨噬细胞移动抑制因子（MIF）的浓度。
采用酶联免疫吸附测定法（ELISA）检测外周血MIF的回顾性研究。
妇科诊所和人类生殖研究实验室。
38名正常女性和55名子宫内膜异位症女性。
在腹腔镜检查前几天采集外周血样本。
血清中的MIF浓度。
本研究显示，与正常女性相比，子宫内膜异位症女性的MIF浓度增加了364%。在子宫内膜异位症I-II期有显著增加，但在疾病更晚期（III-IV期）观察到更明显的增加。患有子宫内膜异位症的生育期和不孕女性的MIF水平均高于正常对照组，但在患有子宫内膜异位症的不孕女性中差异更显著。无盆腔疼痛的子宫内膜异位症女性的MIF水平高于正常对照组，但报告有盆腔疼痛的子宫内膜异位症女性的MIF水平增加更为显著。
本研究显示子宫内膜异位症女性外周血中MIF浓度显著增加，且与疾病进展有关，并提示MIF可能与子宫内膜异位症相关的疼痛和不孕有关。
