Suzuki Takahiro, Izumi Shun-ichiro, Matsubayashi Hidehiko, Awaji Hideo, Yoshikata Kikuo, Makino Tsunehisa
Department of Obstetrics and Gynecology, Specialized Clinical Science, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa 259-1193, Japan.
Fertil Steril. 2005 Apr;83(4):908-13. doi: 10.1016/j.fertnstert.2004.11.028.
To evaluate the effect of endometriosis and the presence of an ovarian endometrioma on outcomes of conventional in vitro fertilization (IVF).
Retrospective study.
Reproductive Unit, Department of Obstetrics and Gynecology, Tokai University Hospital.
PATIENT(S): Group A: 80 cycles with ovarian endometriomas; group B: 248 cycles with endometriosis but without endometrial cysts at the time of oocyte retrieval; group C: 283 cycles undergoing IVF because of tubal factor without endometriosis.
INTERVENTION(S): All conventional in vitro fertilization-embryo transfer (IVF-ET) with previous diagnostic laparoscopy. An endometrioma was diagnosed by direct aspiration at the time of oocyte retrieval.
MAIN OUTCOME MEASURE(S): Retrieved number of oocytes, fertilization rate, embryo quality, implantation rate, pregnancy rate, and live birth rate for all cases. In group A, the number of retrieved oocytes in relation to the volume of the endometrioma and affected laterality.
RESULT(S): Fewer oocytes were retrieved from groups A and B than from group C (P<.005). The number of retrieved oocytes was not dependent on the volume of endometrial cyst(s). Fertilization rates were similar among the groups. Group A had slightly but not significantly higher rates of morphologically good-quality embryos (group A: 67.2%, group B: 63.0%, group C: 58.1%), implantation (group A: 14.1%, group B: 11.7%, group C: 11.3%), and pregnancy (group A: 25.3%, group B: 22.3%, group C: 23.9%).
CONCLUSION(S): Endometriosis affects oocyte number but not embryo quality or pregnancy outcome, irrespective of the presence of an ovarian endometrioma.
评估子宫内膜异位症及卵巢子宫内膜异位囊肿的存在对常规体外受精（IVF）结局的影响。
回顾性研究。
东海大学医院妇产科生殖科。
A组：80个周期伴有卵巢子宫内膜异位囊肿；B组：248个周期患有子宫内膜异位症但在取卵时无子宫内膜囊肿；C组：283个周期因输卵管因素接受IVF且无子宫内膜异位症。
所有患者均接受过诊断性腹腔镜检查，之后进行常规体外受精 - 胚胎移植（IVF - ET）。在取卵时通过直接抽吸诊断子宫内膜异位囊肿。
所有病例的取卵数、受精率、胚胎质量、着床率、妊娠率和活产率。在A组中，取卵数与子宫内膜异位囊肿的体积及患侧的关系。
A组和B组的取卵数少于C组（P <.005）。取卵数不取决于子宫内膜囊肿的体积。各组的受精率相似。A组形态学优质胚胎率（A组：67.2%，B组：63.0%，C组：58.1%）、着床率（A组：14.1%，B组：11.7%，C组：11.3%）和妊娠率（A组：25.3%，B组：22.3%，C组：23.9%）略高，但差异无统计学意义。
子宫内膜异位症会影响卵母细胞数量，但不影响胚胎质量或妊娠结局，无论是否存在卵巢子宫内膜异位囊肿。
