高效抗逆转录病毒疗法（HAART）治疗后血清细胞因子水平的蛋白质组学分析。
Proteomic analysis of serum cytokine levels in response to highly active antiretroviral therapy (HAART).
作者信息
Relucio Karen I, Beernink Hans T, Chen Donna, Israelski Dennis M, Kim Raymond, Holodniy Mark
机构信息
Divison of Infectious Diseases and Geographic Medicine, Stanford University, Stanford, California, USA.
出版信息
J Proteome Res. 2005 Mar-Apr;4(2):227-31. doi: 10.1021/pr049930y.
A 30-cytokine protein microarray was used to screen for cytokine profile changes in HIV-infected patients in response to highly active antiretroviral therapy (HAART). Serum cytokines showing significant changes were confirmed by enzyme immunoassay. Monokine induced by gamma-interferon (MIG) and interferon-inducible protein-10 (IP-10) levels significantly decreased after 24 weeks of HAART. Protein microarrays are useful for initial screening of novel cytokine expression. Further studies are needed to elucidate the role of MIG and IP-10 in response to HAART.
使用一种包含30种细胞因子的蛋白质微阵列来筛选接受高效抗逆转录病毒疗法（HAART）的HIV感染患者的细胞因子谱变化。通过酶免疫测定法确认显示出显著变化的血清细胞因子。接受HAART 24周后，γ干扰素诱导的单核细胞趋化蛋白（MIG）和干扰素诱导蛋白10（IP-10）水平显著降低。蛋白质微阵列可用于新型细胞因子表达的初步筛选。需要进一步研究以阐明MIG和IP-10在对HAART反应中的作用。
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