Zhou Z G, Wu H W, Chao C S
Department of Endocrinology, Second Affiliated Hospital, Hunan Medical University, Changsha.
Zhonghua Nei Ke Za Zhi. 1992 Oct;30(10):634-6, 659.
Risk factors of tissue hypoxia was investigated in 26 patients with diabetic retinopathy (DMR), who compared with 62 patients without DMR. significant higher incidence of DMR was found in patients with poor diabetic control (HbA 1 greater than or equal to 10%), with orthostatic hypotension (OH), with peripheral neuropathy and with atherosclerosis respectively. Erythrocyte 2,3-diphosphoglycerate (2,3-DPG) was lower (P less than 0.05) and venous oxygen tension in pedal dorsum (PvO2) higher (P less than 0.05) in DMR patients than those in uncomplicated DMR patients and normal subjects. There was a rank correlation between DMR severity and PvO2 (r = 0.429, P less than 0.05), which imply that decreased blood oxygen utilization may be related to diabetic microangiopathy. These data suggested that abnormal changes of HbA 1 and 2,3-DPG, decrease of peripheral blood oxygen utilization, atherosclerosis, OH and neuropathy might be risk factors of tissue hypoxia in DMR patients.
对26例糖尿病视网膜病变（DMR）患者的组织缺氧危险因素进行了研究，将其与62例无DMR的患者进行比较。结果发现，糖尿病控制不佳（糖化血红蛋白A1大于或等于10%）、患有体位性低血压（OH）、患有周围神经病变和患有动脉粥样硬化的患者中DMR的发生率显著更高。与无并发症的DMR患者和正常受试者相比，DMR患者的红细胞2,3-二磷酸甘油酸（2,3-DPG）较低（P<0.05），足背静脉血氧张力（PvO2）较高（P<0.05）。DMR严重程度与PvO2之间存在等级相关性（r=0.429，P<0.05），这意味着血液氧利用率降低可能与糖尿病微血管病变有关。这些数据表明，糖化血红蛋白A1和2,3-DPG的异常变化、外周血氧利用率降低、动脉粥样硬化、OH和神经病变可能是DMR患者组织缺氧的危险因素。
