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[糖尿病中的糖化血红蛋白与红细胞2,3-二磷酸甘油酸]

[Glycosylated hemoglobins and erythrocyte 2,3-diphosphoglycerate in diabetes mellitus].

作者信息

Triolo G, Giardina E, Contorno A, Cipolla T, Giannuoli G, Caimi G, Catania A, Rinaldi A

出版信息

Arch Sci Med (Torino). 1981 Apr-Jun;138(2):179-85.

PMID:7018462
Abstract

Investigations carried out on 43 diabetic not ketoacidotic patients (32 women and 11 men) showed that the percentage of glycosylated hemoglobins (GHb) is significantly (p less than 0.01) inversely related to the intra-erythrocytic concentration of 2,3-DPG and to the calculated P50. Preliminary data from a prospective study suggest that the inverse relationship could be referred to the degree of control of the disease. In poorly controlled diabetes, where at the highest percentages of GHb the lowest levels of 2,3-DPG are found, less oxigen can be delivered to peripheral tissues.

摘要

对43例非酮症酸中毒糖尿病患者(32例女性,11例男性)进行的研究表明,糖化血红蛋白(GHb)的百分比与红细胞内2,3 - 二磷酸甘油酸(2,3-DPG)的浓度以及计算得出的P50呈显著负相关(p小于0.01)。一项前瞻性研究的初步数据表明,这种负相关可能与疾病的控制程度有关。在控制不佳的糖尿病中,GHb百分比最高时2,3-DPG水平最低,此时输送到外周组织的氧气较少。

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1
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Arch Sci Med (Torino). 1981 Apr-Jun;138(2):179-85.
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