Chhatwal Gursharan S, McMillan David J
Department of Microbial Pathogenesis and Vaccine Research, GBF German Research Centre for Biotechnology, Mascheroder Weg 1, 38124 Braunschweig, Germany.
Trends Mol Med. 2005 Apr;11(4):152-5. doi: 10.1016/j.molmed.2005.02.001.
Group A streptococci, although considered extracellular pathogens, are capable of causing severe life-threatening invasive infections, such as necrotising fasciitis, bacteraemia and toxic-shock-like syndrome. A complete understanding of the mechanism by which these organisms cause invasive disease has been hampered by the extreme human specificity and high genetic diversity among group A streptococci. Three recent papers have uncovered some of the mysteries of streptococcal invasive diseases. Using two different technologies, these papers have contributed enormously towards our understanding of the molecular events underlying streptococcal invasive diseases.
A组链球菌虽然被认为是细胞外病原体，但能够引发严重的、危及生命的侵袭性感染，如坏死性筋膜炎、菌血症和中毒性休克样综合征。由于A组链球菌具有极强的人类特异性和高度的遗传多样性，对这些病原体导致侵袭性疾病的机制的全面理解受到了阻碍。最近的三篇论文揭示了链球菌侵袭性疾病的一些奥秘。通过使用两种不同的技术，这些论文为我们理解链球菌侵袭性疾病背后的分子事件做出了巨大贡献。
