Vinh Donald C, Embil John M
Curr Infect Dis Rep. 2006 Sep;8(5):375-83. doi: 10.1007/s11908-006-0048-y.
Skin and soft tissue infections (SSTIs) span a broad spectrum of clinical entities from limited cellulitis to rapidly progressive necrotizing fasciitis, which may be associated with septic shock or a toxic shock-like syndrome. These infections may manifest initially as pyodermas that then progress; alternatively, they may arise from metastatic spread of microorganisms from a distant focus. Regardless of the source, SSTIs may lead to critical illness. The complex interplay of environment, host, and pathogen are important to consider when evaluating SSTIs and planning appropriate therapy. The keys to a successful outcome are early identification of risk factors for specific pathogens and early initiation of empiric antimicrobial therapy. For certain types of SSTIs, surgical intervention for diagnosis and/or therapy is also required.
皮肤和软组织感染（SSTIs）涵盖了广泛的临床病症，从局限性蜂窝织炎到迅速进展的坏死性筋膜炎，后者可能与感染性休克或中毒性休克样综合征相关。这些感染最初可能表现为脓疱病，随后进展；或者，它们可能源于微生物从远处病灶的转移性扩散。无论来源如何，SSTIs都可能导致危重病。在评估SSTIs和规划适当治疗时，环境、宿主和病原体之间复杂的相互作用是需要考虑的重要因素。成功治疗的关键是早期识别特定病原体的危险因素，并尽早开始经验性抗菌治疗。对于某些类型的SSTIs，还需要进行手术干预以进行诊断和/或治疗。
