Weissenbacher Stephanie, Bacon Theresa, Targett Darren, Behrendt Heidrun, Ring Johannes, Darsow Ulf
Department of Dermatology and Allergy, Biederstein Technical University, D-80802 Munich, Germany.
Acta Derm Venereol. 2005;85(2):147-51. doi: 10.1080/00015550410024418.
We evaluated the reproducibility of atopy patch test reactions and the quality and quantity of itch in 16 patients with atopic eczema and a history of a positive atopy patch test reaction, comparing three different application sites. The allergen was re-applied simultaneously on both forearms and the back. Intensity and quality of pruritus were evaluated using a visual analogue scale and the Eppendorf itch questionnaire, respectively. The atopy patch test reaction was highly reproducible, occurring in 15/16 (94%) patients. Pruritus was reported by 14/16 (88%) patients. There was no significant difference in either the intensity or quality of itch between the two forearms and the back (p>0.05). The mean peak visual analogue scale itch score was comparable across all three test sites (range 28.3-31.9). Regarding quantification of test reactions, a positive reaction was more frequent on the back (94% versus 69% on the arms) and the peak atopy patch test score was higher on the back compared with the arms (right forearm, p=0.0018 and left forearm, p=0.0683). Allergens should preferably be applied on the back for the atopy patch test. However, the atopy patch test can induce atopic itch irrespective of the application site.
我们评估了16例患有特应性皮炎且有特应性斑贴试验阳性反应史的患者中，特应性斑贴试验反应的可重复性以及瘙痒的质量和程度，比较了三个不同的敷用部位。将变应原同时重新敷用于双侧前臂和背部。分别使用视觉模拟评分法和Eppendorf瘙痒问卷评估瘙痒的强度和质量。特应性斑贴试验反应具有高度可重复性，16例患者中有15例（94%）出现反应。16例患者中有14例（88%）报告有瘙痒。双侧前臂和背部之间瘙痒的强度或质量均无显著差异（p>0.05）。所有三个试验部位的视觉模拟评分法瘙痒峰值平均得分相当（范围28.3 - 31.9）。关于试验反应的量化，背部出现阳性反应更为频繁（94%，而手臂为69%），且与手臂相比，背部的特应性斑贴试验峰值评分更高（右侧前臂，p = 0.0018；左侧前臂，p = 0.0683）。进行特应性斑贴试验时，变应原最好敷用于背部。然而，无论敷用部位如何，特应性斑贴试验均可诱发特应性瘙痒。
