Fox C L, Modak S M
Antimicrob Agents Chemother. 1974 Jun;5(6):582-8. doi: 10.1128/AAC.5.6.582.
The role of silver and sulfadiazine in the mechanism of action of silver sulfadiazine on burn wound infections was investigated. Silver, but not sulfadiazine, was bound by bacteria. Sulfadiazine did not act as an antibacterial agent in low concentrations, but exhibited specific synergism in combination with subinhibitory levels of silver sulfadiazine. The efficacy of silver sulfadiazine is thought to result from its slow and steady reactions with serum and other sodium chloride-containing body fluids, which permits the slow and sustained delivery of silver ions into the wound environs. In this circumstance, a relatively minute amount of sulfadiazine appears active.
研究了银和磺胺嘧啶在磺胺嘧啶银对烧伤创面感染作用机制中的作用。细菌能结合银，但不能结合磺胺嘧啶。低浓度时，磺胺嘧啶不具有抗菌作用，但与亚抑菌浓度的磺胺嘧啶银联合使用时表现出特异性协同作用。磺胺嘧啶银的疗效被认为源于其与血清和其他含氯化钠体液的缓慢而稳定的反应，这使得银离子能够缓慢而持续地输送到伤口周围环境中。在这种情况下，相对少量的磺胺嘧啶似乎具有活性。
