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Determination of the base composition of deoxyribonucleic acid from its buoyant density in CsCl.根据脱氧核糖核酸在氯化铯中的浮力密度测定其碱基组成。
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SPECTROPHOTOMETRIC STUDIES OF THE INTERACTION OF CHLOROQUINE WITH DEOXYRIBONUCLEIC ACID.氯喹与脱氧核糖核酸相互作用的分光光度研究
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磺胺嘧啶银：与分离的脱氧核糖核酸的相互作用

Silver sulfadiazine: interaction with isolated deoxyribonucleic acid.

作者信息

Rosenkranz H S, Rosenkranz S

出版信息

Antimicrob Agents Chemother. 1972 Nov;2(5):373-83. doi: 10.1128/AAC.2.5.373.

DOI:10.1128/AAC.2.5.373
PMID:4677596
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC444323/
Abstract

Silver sulfadiazine (AgSu) was found to interact with isolated deoxyribonucleic acid (DNA) to form nondissociable complexes. These complexes differ in physical and chemical properties from those that are established when silver nitrate is added to DNA. The reaction between AgSu and DNA is visualized as occurring in two stages: (i) a weak and reversible interaction (intercalation) between DNA and the sulfadiazine moiety and (ii) a tight binding involving the silver atom. In the first stage, sodium sulfadiazine competes with AgSu for the DNA.

摘要

发现磺胺嘧啶银（AgSu）与分离出的脱氧核糖核酸（DNA）相互作用形成不可解离的复合物。这些复合物的物理和化学性质与向DNA中添加硝酸银时形成的复合物不同。AgSu与DNA之间的反应被认为分两个阶段发生：（i）DNA与磺胺嘧啶部分之间的弱且可逆的相互作用（嵌入），以及（ii）涉及银原子的紧密结合。在第一阶段，磺胺嘧啶钠与AgSu竞争DNA。