Duncan Robert B, Scarratt William K, Buehring Gertrude C
Department of Biomedical Sciences and Pathobiology, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Tech, Blacksburg, VA 24061, USA.
J Vet Diagn Invest. 2005 Mar;17(2):190-4. doi: 10.1177/104063870501700217.
An 18-month-old bovine heifer was presented for clinical evaluation after a sudden onset of ventral edema. Clinical and pathological evaluations were consistent with thymic lymphosarcoma, a sporadic form of lymphosarcoma in cattle, which is not generally considered to be associated with bovine leukemia virus (BLV). This heifer was seropositive for BLV at 6 and 18 months of age. Tissues obtained at necropsy were evaluated using in situ polymerase chain reaction. The BLV proviral DNA was detected in lymphocytes of the thymus as well as in epithelial cells of the liver and kidney. This report presents evidence that thymic lymphosarcomas can be associated with BLV infection and that BLV may have a broader cellular tropism than was supposed previously.
一头18月龄的小母牛在突然出现腹部水肿后接受临床评估。临床和病理评估结果与胸腺淋巴肉瘤相符，这是牛淋巴肉瘤的一种散发形式，一般认为与牛白血病病毒（BLV）无关。这头小母牛在6月龄和18月龄时BLV血清学检测呈阳性。对尸检获得的组织进行原位聚合酶链反应评估。在胸腺淋巴细胞以及肝脏和肾脏的上皮细胞中检测到了BLV前病毒DNA。本报告提供的证据表明，胸腺淋巴肉瘤可能与BLV感染有关，并且BLV的细胞嗜性可能比以前认为的更广。
