Corasaniti M T, Strongoli M C, Pisanelli A, Bruno P, Rotiroti D, Nappi G, Nisticò G
Department of Experimental and Clinical Medicine, Faculty of Medicine and Surgery, University of Reggio Calabria, Rome, Italy.
Funct Neurol. 1992 Jan-Feb;7(1):51-6.
Paraquat concentrations were determined in specific brain areas of rats systemically treated with different doses of the herbicide and sacrificed at different time periods following the acute administration. The systemic treatment with paraquat gave rise to a regional differential distribution of the herbicide into the rat brain, the highest levels being detected in the prefrontal cortex and hypothalamus. The rate of paraquat elimination showed time-dependency in the prefrontal cortex and hypothalamus; by contrast, in the other regions studied the initial drop observed at 3 h was followed by a second phase of significant accumulation. The concentrations detected into the cortex may account for the neuronal cell death reported in rats following systemic injection of this herbicide.
在急性给药后不同时间段处死经不同剂量除草剂全身处理的大鼠，测定其特定脑区中的百草枯浓度。百草枯全身处理导致该除草剂在大鼠脑中出现区域差异分布，在前额叶皮质和下丘脑检测到的水平最高。百草枯在前额叶皮质和下丘脑的消除率呈时间依赖性；相比之下，在其他研究区域，3小时时观察到的初始下降之后是第二阶段的显著蓄积。在皮质中检测到的浓度可能解释了全身注射该除草剂后大鼠中报道的神经元细胞死亡情况。
