Firlik M
Z Kliniki Pneumonologii Instytutu Chorób Wewnetrznych AM w Poznaniu.
Pneumonol Pol. 1990 Apr-May;58(4-5):185-91.
The toxic effect of paraquat aerosol was studied in 30 rats using three different concentration: 3 mg, 15 mg and 30 mg. Extensive lung involvement was observed in rats exposed to medium and high doses, which in most animals was fatal. In 2 rats exposed to the small concentrations of paraquat on the 15th day atelectasis and cellular infiltrations in the lung parenchyma were found. These changes could not be found in rats sacrificed on the 29th day of the experiment. The results of this study show that even low doses of paraquat may injure the respiratory system, producing changes that are symptom free.
使用三种不同浓度(3毫克、15毫克和30毫克)对30只大鼠研究了百草枯气雾剂的毒性作用。在暴露于中高剂量的大鼠中观察到广泛的肺部受累,大多数动物因此死亡。在第15天暴露于低浓度百草枯的2只大鼠中,发现肺实质出现肺不张和细胞浸润。在实验第29天处死的大鼠中未发现这些变化。本研究结果表明,即使是低剂量的百草枯也可能损伤呼吸系统,产生无症状的变化。