Schuster-Böckler Benjamin, Bateman Alex
The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
Bioinformatics. 2005 Jun 15;21(12):2912-3. doi: 10.1093/bioinformatics/bti434. Epub 2005 Apr 12.
The availability of advanced profile-profile comparison tools, such as PRC or HHsearch demands sophisticated visualization tools not presently available. We introduce an approach built upon the concept of HMM logos. The method illustrates the similarities of pairs of protein family profiles in an intuitive way. Two HMM logos, one for each profile, are drawn one upon the other. The aligned states are then highlighted and connected.
A web interface offering online creation of pairwise HMM logos is available at http://www.sanger.ac.uk/Software/analysis/logomat-p. Furthermore, software developers may download a Perl package that includes methods for creation of pairwise HMM logos locally.
先进的轮廓-轮廓比较工具，如PRC或HHsearch的可用性需要复杂的可视化工具，而目前这些工具尚不存在。我们引入了一种基于HMM标志概念的方法。该方法以直观的方式展示了蛋白质家族轮廓对之间的相似性。绘制两个HMM标志，每个轮廓一个，将它们叠加在一起。然后突出显示并连接对齐的状态。
