Krause G, Martin L, Fritzler M, Hart D A
Joint Injury and Diseases Research Group, Faculty of Medicine, University of Calgary, Alberta, Canada.
Int J Immunopharmacol. 1992 Jan;14(1):35-41. doi: 10.1016/0192-0561(92)90102-q.
Murine models of systemic lupus erythematosus (SLE) exhibit some, but not all, of the characteristics of human disease. Disease progression in the animal models is regulated by autoantibodies, genetics and inflammatory processes. In the present study, the influence of the pyridine extract residue of Corynebacterium parvum Type I (CP-PER) on disease progression in the NZB/W model of SLE was investigated. CP-PER is known to activate the reticuloendothelial (RE) system of mice and can alter a number of host responses. Injection of NZB/W females with CP-PER at 10 weeks of age, prior to the onset of overt disease, led to a transient activation of the RE system which then appeared to return to levels observed in untreated animals. Sera from treated and untreated animals were analyzed for anti-nuclear antibodies, and anti-ssDNA antibodies. The most prominant change in the treated animals was an increase in the titer of anti-ssDNA. On average, animals in the early treatment group also lived somewhat longer than those in the untreated control group. Treatment of animals with CP-PER at 6 months of age, when the disease was evident, again led to transient RES activation and an altered autoantibody profile. Animals treated with CP-PER at 6 months of age exhibited a slightly accelerated death rate when compared with the untreated controls. These results indicate that bacterial response modifiers such as C. parvum-PER, which contains primarily the RES activating activity of C. parvum, can alter disease progression in the NZB/W model.
系统性红斑狼疮（SLE）的小鼠模型展现出了人类疾病的一些而非全部特征。动物模型中的疾病进展受自身抗体、遗传学和炎症过程调控。在本研究中，对I型微小棒状杆菌的吡啶提取物残渣（CP-PER）对SLE的NZB/W模型中疾病进展的影响进行了研究。已知CP-PER可激活小鼠的网状内皮（RE）系统，并能改变许多宿主反应。在明显疾病发作之前，于10周龄给NZB/W雌性小鼠注射CP-PER，导致RE系统短暂激活，随后似乎恢复到未处理动物中观察到的水平。对处理和未处理动物的血清进行抗核抗体和抗单链DNA抗体分析。处理组动物中最显著的变化是抗单链DNA滴度增加。平均而言，早期处理组的动物也比未处理的对照组动物存活时间稍长。在6月龄疾病明显时用CP-PER处理动物，再次导致RE系统短暂激活和自身抗体谱改变。与未处理的对照组相比，6月龄用CP-PER处理的动物死亡率略有加速。这些结果表明，诸如微小棒状杆菌-PER这类主要含有微小棒状杆菌RE激活活性的细菌反应调节剂，可改变NZB/W模型中的疾病进展。
