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麻黄所致急性肝衰竭需进行肝移植。

Ma huang associated acute liver failure requiring liver transplantation.

作者信息

Skoulidis Ferdinandos, Alexander Graeme J M, Davies Susan E

机构信息

Addenbrooke's Hospital, Cambridge, UK.

出版信息

Eur J Gastroenterol Hepatol. 2005 May;17(5):581-4. doi: 10.1097/00042737-200505000-00017.

DOI:10.1097/00042737-200505000-00017
PMID:15827451
Abstract

An ever increasing number of herbal remedies are recognized as potentially hepatotoxic. We report a case of fulminant hepatic failure requiring liver transplantation associated with the use of Ma huang, a traditional Chinese remedy containing ephedrine-type alkaloids. The literature surrounding the potential liver toxicities of Ma huang is reviewed and the proposed pathogenetic mechanisms are critically examined.

摘要

越来越多的草药疗法被认为具有潜在的肝毒性。我们报告一例暴发性肝衰竭病例,该病例需要进行肝移植,其与使用含有麻黄碱类生物碱的传统中药麻黄有关。本文回顾了围绕麻黄潜在肝脏毒性的文献,并对提出的发病机制进行了严格审查。

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1
Ma huang associated acute liver failure requiring liver transplantation.麻黄所致急性肝衰竭需进行肝移植。
Eur J Gastroenterol Hepatol. 2005 May;17(5):581-4. doi: 10.1097/00042737-200505000-00017.
2
Acute hepatitis associated with the use of a Chinese herbal product, ma-huang.与使用一种中草药产品麻黄相关的急性肝炎。
Am J Gastroenterol. 1996 Jul;91(7):1436-8.
3
Cytotoxicity assessment of Ma-huang (Ephedra) under different conditions of preparation.不同制备条件下麻黄的细胞毒性评估。
Toxicol Sci. 2000 Aug;56(2):424-30. doi: 10.1093/toxsci/56.2.424.
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Protective effect of gui zhi (Ramulus Cinnamomi) on abnormal levels of four amino acid neurotransmitters by chronically ma huang (Herb Ephedra) intoxicated prefrontal cortex in rats treated with a ma huang-gui zhi herb pair.桂枝对慢性麻黄中毒大鼠前额叶皮层四种氨基酸神经递质异常水平的保护作用。用麻黄-桂枝药对治疗。
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Probable herbal medication induced fulminant hepatic failure.
J Paediatr Child Health. 2005 Sep-Oct;41(9-10):530-1. doi: 10.1111/j.1440-1754.2005.00698.x.
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Psychiatric complications of Ma-huang.麻黄的精神科并发症。
Psychosomatics. 2000 Jan-Feb;41(1):58-62. doi: 10.1016/S0033-3182(00)71174-1.
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Nonpigmenting solitary fixed drug eruption caused by a Chinese traditional herbal medicine, ma huang (Ephedra Hebra), mainly containing pseudoephedrine and ephedrine.由主要含有伪麻黄碱和麻黄碱的中国传统草药麻黄引起的无色素沉着性孤立性固定性药疹。
J Am Acad Dermatol. 2003 Apr;48(4):628-30. doi: 10.1067/mjd.2003.192.
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Ma-huang strikes again: ephedrine nephrolithiasis.麻黄再次作祟:麻黄碱肾结石症
Am J Kidney Dis. 1998 Jul;32(1):153-9. doi: 10.1053/ajkd.1998.v32.pm9669437.
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Adverse cardiovascular and central nervous system events associated with dietary supplements containing ephedra alkaloids.与含有麻黄生物碱的膳食补充剂相关的不良心血管和中枢神经系统事件。
N Engl J Med. 2000 Dec 21;343(25):1833-8. doi: 10.1056/NEJM200012213432502.
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Severe hepatotoxicity associated with the use of weight loss diet supplements containing ma huang or usnic acid.与使用含有麻黄或松萝酸的减肥膳食补充剂相关的严重肝毒性。
J Hepatol. 2004 Dec;41(6):1062-4. doi: 10.1016/j.jhep.2004.06.028.

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Herb-induced liver injury: Systematic review and meta-analysis.草药性肝损伤:系统评价与荟萃分析。
World J Clin Cases. 2021 Jul 16;9(20):5490-5513. doi: 10.12998/wjcc.v9.i20.5490.
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Integrating traditional Chinese medicines into professional community pharmacy practice in China - Key stakeholder perspectives.
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Eur J Integr Med. 2020 Feb;34:101063. doi: 10.1016/j.eujim.2020.101063. Epub 2020 Feb 5.
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Clin Liver Dis (Hoboken). 2016 Nov 10;8(Suppl 1):S30-S33. doi: 10.1002/cld.597. eCollection 2016 Nov.
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Liver injury due to herbal and dietary supplements: A review of individual ingredients.草药和膳食补充剂导致的肝损伤:单一成分综述
Clin Liver Dis (Hoboken). 2016 Apr 27;7(4):80-83. doi: 10.1002/cld.541. eCollection 2016 Apr.
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Sympathomimetic amine compounds and hepatotoxicity: Not all are alike-Key distinctions noted in a short review.拟交感神经胺类化合物与肝毒性:并非所有都相同——一篇简短综述中指出的关键区别
Toxicol Rep. 2018 Dec 1;6:26-33. doi: 10.1016/j.toxrep.2018.11.013. eCollection 2019.
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Traditional Chinese Medicine (TCM) and Herbal Hepatotoxicity: RUCAM and the Role of Novel Diagnostic Biomarkers Such as MicroRNAs.传统中医与草药肝毒性:RUCAM及微小RNA等新型诊断生物标志物的作用
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