Van der Meersch H
Centre d'lnformation Pharmaceutique APB.
J Pharm Belg. 2005;60(1):23-9.
This article reviews the development of the artemisinins used in the treatment of drug-resistant Plasmodium falciparum malaria. The story starts in China with Artemisia annua L., a plant that was traditionally used as an antipyretic. The activity of Annual wormwood can be explained by the presence of the active substance artemisinin. Soon, artemether, artemotil, artenimol, artesunate and sodium artesunate, derivatives of artemisinin, have been developed. Each has its own physical and pharmaceutical properties, dosage and dosage forms. Other aspects, such as the general guidelines for use, safety during pregnancy and the perspectives of artemisinin compounds, are being discussed.
本文综述了用于治疗耐多药恶性疟原虫疟疾的青蒿素类药物的发展历程。故事始于中国的黄花蒿，这种植物传统上用作退烧药。黄花蒿的活性可归因于活性物质青蒿素的存在。很快，青蒿素的衍生物蒿甲醚、蒿乙醚、本芴醇、青蒿琥酯和青蒿琥酯钠相继被研发出来。每种衍生物都有其自身的物理和药学性质、剂量及剂型。文中还讨论了其他方面，如使用的一般指南、孕期安全性以及青蒿素类化合物的前景。
